Another Claymore known as Teresa has appeared in a town where she quickly dispatches a Yoma, with no effort. She is well-known as for her nickname "Teresa of the Faint Smile" because she never releases her Yoma powers. In the town of Teo, as soon as she arrives there she ruthlessly attacks any Yoma she senses and after the massacre a girl with no name who was with one of the Yoma seems to be very attached to Teresa. This girl ends up following Teresa no matter what she did.

After naming the girl who was following her, Claire; Teresa is heading towards the town of Rokut to drop her off. At night while they are resting in the woods, the man whose arm was chopped off is back for revenge. It turns out that the girl was able to save her and not from the man but to save her lonely heart. Teresa later encounters the bandits but this time they have done something unforgivable which forces Teresa to do something unforgivable.

Two more Claymores have appeared, Sophia and Noel who have entered a town that has become a Yoma hive, don't require much effort to eradicate the hordes of Yoma. There are still some Yoma left but that is until Irene nicknamed, "Flash Sword Irene" finishes them off. Following Teresa's betrayal, the number 2-5 Claymores have gathered with orders to execute Teresa, but who is the remaining Claymore yet to arrive? The ultimate battle between Claymores is about to begin.

The team of Claymore reach the mountains and are surprised by what they encounter, a Male Awakened One. Another Claymore and a handler are watching the battle from a distance, but what do they appear to be plotting? The battle reaches its climatic stage, with all but the "Phantom Miria", badly wounded. This may be what the Awakened meant by "true despair", however Claire is one to know what true despair is really like and this is not it.

Following her recent experience in the mountains Claire is back to her jobs of taking care of Yoma, accompanied by Raki. In the light of her recent change in personality Claire has been given a job to hunt down another Awakened One, North to the village of Gonahl. As she reaches the rendezvous point, Claire is greeted by a lone Claymore and to her surprise it is non-other than the Claymore who lust for blood and battle, no.4 "Ophelia".

Claire continues her intensive training with the former no .2 Irene and she doesn't seem to be improving much, without her dominant arm. Claire and Irene later part ways but not before Claire is given a farewell gift. It doesn't take long for Claire to run into some trouble again; however this time it's something monstrous yet someone she has already encountered. Will Claire prove that she is qualified to fight?

Claire has joined the hunt for the Awakened One, in the mountains of Zakol, to save the no. 9 "Jeane". Things seem odd to begin with, as Claire enters the eerie lair, with an irregular Yoki flowing everywhere and the fight begins once she finds the source of the Yoki. Even with the Flash Sword it appears impossible for Claire to defeat her foe however the tables turn with the arrival of no. 3 "Galatea". More is revealed about the powerful Awakened One in the mountains and the reason why it's gathering more Awakened beings.

Awakened Beings have launched a surprise attack on the city of Pieta, forcing the teams of Claymores to begin their battles against these unbeatable creatures. Even with these incredibly powerful Awakened Beings to fight against there may be some Claymores who are able to handle this sort of situation, which will only get tougher in the future.

Having just heard the news of what happened in the City of Pieta, Isley has ordered his entire army of 27 Awakened beings to annihilate the Claymores located there. With the probability of this mission ending in success zero, no matter the odds the teams of Claymores are still determined to carve out their path of survival. Meanwhile Raki is heading towards Pieta with Isley and Priscilla when he later discovers something shocking.

The fight rages on and while battling with the unbeatable Rigardo, Claire has inadvertently awakened partially and dealt a deadly blow. With her new found abilities Claire has proven herself to be a great adversary for the "The Silver-Eyed Lion King", so now he is finally able to go all-out.