009-1 is on vacation in Rome when she meets up with a girl who is being chased by some men. She helps her out and in the process runs into 009-4 who is staking out someone. She discovers that the woman is in fact an android made of gold and must use everything she can to bring her down.

Eastern Block forces arrive at the research facility having realized that that is the most likely place the "reverse-explosion" machine is. 009-1 refuses to evacuate and stays with the kids. She learns that Dr Green has a way out and follows with the kids. Once outside she battles the Eastern forces so that the kids can escape. She gets a little help from Loki along the way.