After God forgets the Devil's birthday, the Devil decides to go back to hell and take all the world's evil to show God how much he really needs him. Up in the world, Bob is realizing how everyone is much too nice, which eventually gets on Bob's nerves. So, he launches on a quest to reunite God and the Devil as friends so the Devil returns the world's evil.

After a series of fortunate events that prevented Bob's death, Bob is convinced that his role as God's messenger has granted him the gift of invincibility. All the while, the Devil is frustrated because God never has time for him anymore and he feels that he's being ignored, which once again causes the Devil and Bob's paths to cross.

God is disgusted with how much sex is shown on television and he decides to get Bob to go to Hollywood to get them to limit the amount of sex that can be on television. Bob is reluctant, but he soon comes to his senses when he realizes Andy has seen something he shouldn't, but will he be capable of opposing one of the most powerful people in the world alone?

Bob's father is dying though he doesn't care because his father was always abusive during his life. However, Bob cannot help but wonder if he will go to heaven or hell after he perishes, which causes Bob to go on a journey that may help him understand more about his father than he ever thought he would know.