Cow and Chicken's class takes a field trip to Folsom Prison. There, Chicken changes place with a prisoner, and causes riots by pantsing guards, and demands Pork Butts and Taters for lunch, while the prisoner, Rhode Island Red, pretends to be Chicken. Cow sees through this, and under Super Cow, returns Red, and rescues Chicken.

Boneless Chicken teaches Cow and Chicken how to properly fly kites at Lava Park. When Cow's kite tangles with The Red Guy's Kite, he then uses Boneless as his new kite, and has a kite tug-of-war against the tribe, over the hot-boiling-molten-lava river. Cow and Chicken come to Boneless's rescue, and the tribe wins, while Red Guy takes a dip in the lava river.

Teacher is disappointed when the school's plastic surgery team has no championships, so she calls in The Red Guy, to be the new plastic surgery coach. Chicken and Cow immediately join the team, and are taken to the finals, where they must compete against real doctors, who are still in grade school.

While driving in the snow, Mom and Dad find The Red Guy who says he's heading ""home""; so Mom and Dad take him home with him, and immediately think of him has their new favorite son. Cow and Chicken work together to try to prove The Red Guy's a fraud.

Cow brings home an ""invisible"" dog, whom she dubs, Kevin. Pretty soon, she and Kevin are inseperable, but causes trouble with school and friends. After she enters Kevin in a dog show, and wins, Kevin ""runs away"". Afterwards, Cow finds Kevin, befriended an ""invisible"" homeless man.

Cow and Chicken have a big test the next day at school but when Chicken forgets to study, he tries to fake all kinds of illnesses to avoid going to school. After holding his thermometer over the grill, Mom and Dad call the doctor who makes housecalls: The Red Guy.

Sick of their everyday life of being squirted with milk, Cow's favorite toys: Crabs the Warthog Doll, Piles the Beaver Doll, and Manure the Bear decide to run away to find their original owner. After reading Manure's tag that says ""Made In Hong Kong"", they assume their original owner is a maiden named Hong Kong, and set out on a quest to find her.

It's almost arbor day, and Mom and Dad are feeding their pet piggy pennies so they can crack him open on arbor day. Meanwhile, Cow and Chicken are craving ice cream, and try to chase down the ice cream man (Red Guy).

Chicken trades Cow to a farmer for five Canadian jumping beans. Mom grounds Chicken, and has him throw the beans out. As you guessed, a beanstalk grew, Chicken, Frem, and Earl climbed it, and was captured by Red Guy who is the giant. Super Cow senses this, and flies to the rescue. Flem in the end, ends up laying a golden egg (no, seriously, he LAYS a golden egg).

Dad isn't friendly terms with the new neighbors, who happen to be clowns. Cow falls in love with the clown son, who in return falls in love with Cow. They play hooky to spend the day together. Dad finds out, and Cow in grounded, while he kicks the clown son out, and chews clown dad out.

Mom and Dad are disgusted that Cow and Chicken believe the world is round, so they hire Dad's brother, Longhorn Steer (who really is a steer) to tudor Cow and Chicken. Longhorn fails, but Cow and Chicken learn that he doesn't want to teach...we wants to be a normal steer, get married, have kids, hold a job, and stampede.

Dad tells the story of how he and Mom met to Cow and Chicken.

Now Red Guy's Dr. Hiney, and says that Chicken is a deformed duck. With that, he takes Chicken to the hospital for a wattle-ex-tamy. After hours pass, Red Guy's surgery literally turns Chicken into a duck. Mom and Dad sue Red Guy, and lose. Now the Cow and Chicken show may be renamed "Cow and Duck".

When Cow and Chicken get depressed, their parents suggest them to go to a mysterious swamp, and find a blind blues singer to fight their depression.

The Cow and Chicken`s teacher sings a ballad about Red Guy and Cow and Chicken.