Dan Grat, a gunman hunted by Texas authorities, seeks refuge in Dodge City. Marshal Dillon goes into action against this outlaw who shoots before he talks.

Matt intercedes on behalf of ex-con Cope Borden, when Rance Bradley accuses Cope of horse theft and attempts to lynch him. Cope is proven innocent of the charge, but later kills Bradley's nephew in a fair fight during a gambling dispute. Matt is caught in an awkward situation when he must defend the unsavory Cope against the decent people of Dodge.

Hank Worth, son of wealthy rancher Jake Worth, is kidnapped by three men and held for $20,000 ransom. They shoot him in the back for trying to escape. They call on Doc but Hank dies. The killers decide to let Doc go because he is the only doctor within 400 miles and they fear they might need his services someday. Before sparing his life and freeing him, they force the reluctant Doc to give his word of honor that he will never reveal their identities.

When returning to Dodge, Chester and Matt are confronted by Holly Hawtree, whose father is desperately ill with gangrene. His only hope for survival is amputation of the affected leg. Matt performs the surgery, but the gangrene has spread too far and the old man dies. Matt later discovers that the presumed accident leading to Mr. Hawtree's condition was actually caused by Ben Walling, who has his sights on Holly.

Little Timmy Wyatt witnesses a series of bizarre murders. He has a habit of telling tall tales, so no one will believe him.

Buffalo hunter Jase Murdock is warned by storekeeper Ross to stay out of Indian territory. Matt talks with Murdock's skinner, Golden Calf, who determines that Murdock's medicine is no longer good.

Two bullies cut off Chen's pig-tail, gravely dishonoring him in Chinese culture. Chen vows vengeance.