Upon entering the Grand Line, the ship is swallowed by a giant whale, inside of which they discover a strange place. In addition, they are not the only ones there.

After hearing the story of Laboon the whale, Luffy comes up with a clever solution to his problems. From Laboon's caretaker, Crocus, the crew learns more about the Grand Line and how to navigate through it, since compasses are useless there.

Luffy and friends arrive at Whisky Peak, a town of pirate-lovers who hold them a feast.

Zoro battles a hundred members of Baroque Works, and discovers there is more to them than meets the eye.

Luffy, who does not realize the town is full of bounty hunters, engages in a battle with Zoro after he discovers that Zoro attacked the townsfolk, while Mr. 5 and Miss Valentine head for Princess Vivi.

Luffy's crew manages to become targets of Crocodile, one of the Shichibukai, and decide to help Princess Vivi. They also meet Miss All-Sunday, the second strongest member of Baroque Works and partner of Crocodile.

As Luffy and his crew are sailing in the Grand Line, Koby and Helmeppo are stuck doing odd-jobs for the marines back in East Blue, and encounter Vice-Admiral Garp.

Vice Admiral Garp mentors Koby and Helmeppo to become marines.

Luffy and friends land on Little Garden, a prehistoric island inhabited by dinosaurs and giants.

Nami and Usopp meet a giant named Brogy, while Luffy and Vivi encounter Brogy's rival, Dorry. The Straw Hats little suspect that Officer Agents of Baroque Works are on their tail.

Dorry, critically injured by exploding ale, blames the Straw Hats. Luffy is enraged that someone would pull such a cowardly trick to sabotage the giants' honorable duel.

Luffy tries in vain to convince the injured Dorry not to fight Brogy. The Officer Agents who sabotaged Dorry's ale further tamper with the giants' duel.

Having subdued the giants, Baroque Works makes their move. Mr. 3 introduces Zoro, Nami, Vivi, and Brogy to the slow torture of becoming living statues of wax.

Luffy attempts to rescue his friends but only accelerates the deadly waxing process. To make matters worse, Miss Goldenweek interferes and reveals her own terrifying ability.

Usopp frees Luffy from Miss Goldenweek's control. With Karoo's help, Usopp and Luffy rescue the others, who take on Mr. 5 and Miss Valentine. Luffy and Karoo pursue Mr. 3 and Miss Goldenweek into the forest.

After having a pleasant chat with Mr. 0 and encountering the "Unluckies", Sanji retrieves an Eternal Pose for Alabasta. The crew leaves Little Garden and sets sail for Alabasta.

Nami is sick, but the crew doesn't have a doctor to help her.

While looking for a doctor, the crew meets the pirate Wapol, who attacks them, but only makes Luffy send him flying. Meanwhile Smoker manages to intercept the conversation between Mr. 0 and Sanji and plans to go to Alabasta. Back with the crew they arrive at last to an island only to find out they're not welcome.

The Straw Hat crew manages to gain the trust of the people that attacked them, and are taken to the village, except for Zoro and Carue, who guard the ship. Luffy and Sanji must take Nami to the island's sole doctor who lives on a mountain-top. Vivi and Usopp discover the past of the island, and about the pirate Wapol from Dalton.

While Sanji and Luffy fight off the wilderness, the islander's worst nightmare turns true, as Wapol returns to the island. The doctor is discovered to be on the other side of the island, and Usopp, Vivi and Dalton rush to find her. Dalton however returns as he hears of Wapol's return.

Dalton faces Wapol, but only gets himself hit by arrows thrown by his former comrade Chess. An avalanche stops the battle, but injures Sanji. Luffy must carry both Nami and Sanji to the doctor, and begins his ascent.

The Lapahn help Luffy escape from Wapol, giving him enough time to climb to the castle where doctor Kureha lives. Vivi, Usopp and Zoro deal with the king's army in order to save Dalton. The recovering Nami meets a strange creature.

Nami asks Chopper to join the crew, but he isn't interested. Kureha tells Nami some of what was Chopper's background. After realizing the abilities that Chopper has, Luffy is eager to make him join the crew.

Doctorine continues to tell how Chopper lived his life and how the quack doctor Hiruluk took care of him.

More of Chopper's past is revealed, including the fate of doctor Hiruluk and Wapol's cruelties as the king. Meanwhile, Wapol reaches the castle where the crew is residing.

Wapol is determined to bring down Hiruluk's flag, and to do that, he engages Sanji, Luffy and Chopper in a fight.

Chopper demonstrates the abilities of Rumble Balls when fighting Chessmarimo. Dalton is uncovered from the avalanche.

After trying every trick in the castle, Wapol is finally hunted down by Luffy. The villagers along with Zoro, Vivi and Usopp start their ascent to the castle through a ropeway.

After finally been convinced to join the team, Chopper announces his intentions to Dr. Kureha, who doesn't take it too well; but after escaping from the castle, she has decided to give the whole Straw Hat crew a farewell gift.

Chopper joins the Straw Hat crew as they continue their journey to Vivi's homeland.

Crocodile appears to stop rampaging pirates. Luffy and his crew meet Mr. 2 Bon Clay who shows off his devil fruit power and Vivi sees a shocking sight.