The series begins with the four Sorelli sisters in the midst of their very complicated lives together. Oldest sister Ginnie, a high powered attorney is having difficulty on telling her husband that they are having a baby. Ann is dealing with the fact that her longterm relationship with her boyfriend Danny (guest star Dan Futterman) may be over. Marjee is in a rut on finding a restaurant to host a Pug Dog Benefit featuring Jillian Barbaree that will have live dogs. Also, college student Rose is having a hard time telling the family that she has switched college majors from Pre-Med to the Experimental Theatre Wing.

The sisters are also dealing with the fact that their father, Joe (guest star Tom Irwin, "My So Called Life"), has just announced plans to marry his girlfriend, Renee (Christine Ebersole, Tony Award winner for "42nd Street"), a development that has left the women with conflicting emotions.