When the Sinister Six escape from prison with plans to take down Spider-Man, they nearly succeed. But Peter wakes up with no memory of the battle.

As Christmas approaches, the Sinister Six reconstitutes with Sandman, Rhino, Vulture, Electro and new members Mysterio and Kraven.

A gang war looms as Silver Sable, Hammerhead and Doctor Octopus vie for a prize that could change the balance of power in New York City's underworld.