After surviving a disfiguring gunshot, Dr. Fredrick Chilton is now focused on rallying support to capture Hannibal, using Will as bait. Jack is distracted by Bella's failing health, but he implores Will to abandon the risky idea of finding Hannibal. Meanwhile, Alana Bloom entertains a different approach, potentially partnering with Mason Verger to utilize his vast resources.

The hunt for Hannibal begins. Will travels via train with Chiyoh to Florence, as Alanna and Mason use Hannibal's fine tastes to track his whereabouts. Pazzi tries to get in close to find out if Hannibal is the man he's looking for, but his greed may get the better of him.

With Bedelia securing her alibi, Hannibal prepares to leave Florence just as Jack and Will begin to track him down. With Pazzi murdered, Mason and his cohorts consider a different course of action. However, Chiyoh has arrived in Florence with her own agenda.

Captured in Italy by police on Mason Verger's payroll, Will Graham and Hannibal Lecter are delivered to Muskrat Farm to await Mason's revenge. Alana, distressed that Will has been endangered along with Hannibal, plots a rescue. And Hannibal, once again in contact with his old patient Margot, finds it irresistible to remind her that Mason will never make good on his promises. Meanwhile, Jack informs Chiyo of Hannibal's location.