Mac has more than Thanksgiving turkey on her plate. She juggles military base closures in her home town, a death penalty case the Supreme Court will not hear and a visit with Mom. Joining her team is a young and savvy media strategist/advisor.

A submarine strikes a seamount just off North Korean waters and Mac must ask the Chinese for help. Meanwhile, Dickie's constant need for information has begun to irritate everyone. Meanwhile the first family deals with the question of reelection.

While trying to coordinate the rescue of the crew of a damaged U.S. submarine off the coast of North Korea with help from Chinese, Mac must deal with war fever among her advisors and a leak from China to the North Korean government that threatens to start a nuclear war. Meanwhile, Speaker Templeton’s wife secretly encourages Jayne Murray to accept Nathan’s offer to rejoin his office as chief of Staff.

Mac and Templeton head out west to pay tribute to the dedication of former President Bridges' Presidential Library. While there Air Force One is held hostage by a guy who wants to speak with Mac. Meanwhile Horace and Rebecca have some friends for a party.

While Mac is busy working on her first State of the Union address, Rod becomes a tad tipsy and is found in compromising position with an intern for all the world to see. Meanwhile, Templeton sets out to find a way to sabotage Mac's Homeless Initiative Bill. Plus, Dickie and Jayne, who has gone back to being Templeton's chief-of-staff, go out on a dinner date.

Mac decides to stand by her friend and Attorney General nominee, Carl Brantley, after he gets hammered in his confirmation hearings. A cargo plane which contains military weapons goes missing over Pakistan and it's up to Vice President Keaton to resolve the situation. Meanwhile, Rod tries to settle in the domestic life, but soon faces a crisis when Kate is nowhere to be found.

Mac wants her Attorney General to look into an urban situation in Maryland because it's where Gardner is from. Mac is also briefed on the situation of the missing surface-to-air missiles that went down in a military plane crash over Pakistan and has to make sure that the weapons do not end up in the hands of terrorists. Templeton is ralling support for the Templeton Act which focuses on domestic crime and Mac is threatening to use her veto power in the hopes for more law enforcement and education over the bill's calls for tougher sentencing. Dickie learns that Vince is planning a commitment ceremony with his partner and he warns him not to invite Mac because it might hurt her in the polls.

Mac suffers a burst appendix while aboard Air Force One. Since there is no Vice President in place, Templeton becomes acting President since he is the Speaker of the House and next in line. Meanwhile, there is an air strike that is crippling travel on Memorial Day weekend and Templeton ends up overstepping his bounds and handles the situation the way he wants to.

On Mac's birthday, she is faced with the fact that there are American hostages being held in Turkey by a militant Kurdish group. Meanwhile, she also has to interview new candidates to be her Vice President and Dickie tries to convince her of the type of person she needs to choose because her choice will affect her re-election campaign.

After a critic of the Equal Rights Amendment passes away and his wife takes over his seat, Mac believes she can amend the Constitution and pass the ERA once and for all. Meanwhile Templeton turns a Get Out the Vote campaign meeting into a presidential debate, Rod is asked to write a story about his relationship with Mac, and Rebecca finally learns the identity of her IM buddy, and both are shocked at just who the other person is.