Quando um aniquilador de família sequestra uma adolescente, a Unidade de Análise Comportamental (BAU) trabalha o caso nos dois lados do país para salvá-la. Mas uma conexão improvável com um kit misterioso leva a uma investigação maior, e no centro dela está Penelope Garcia.

Enquanto a equipe caça um criminoso que corta a medula espinhal das vítimas, eles descobrem uma pista de seu último caso que aponta para uma rede de assassinos em série. Para descobrir o tamanho dessa rede, Rossi precisa convencer uma relutante Garcia a fazer a única coisa que ela não quer: voltar para a BAU.

At the heart of the serial killing network is Elias Voit. Dangerous psychopath. Manipulative narcissist. Loving father and husband. In order to find him, the team must find all of his kill kits. But one is missing, and the path leads to a bomb in the middle of Washington, D.C.

A surprising connection forces Deputy Director Bailey to ask the BAU to take a case involving young D.C. socialites who are bitten by a sadistic UnSub. But when the case turns political, the BAU finds themselves in the crosshairs from a high-powered senator. The team is led to a second shipping container that’s rigged to blow.

The explosion looks to have exposed the true mastermind behind Sicarius, but all is not what it seems. Is someone taking the fall for these deadly actions? The BAU is determined to seek the truth.

With the fate of the Sicarius investigation hanging in the balance, the BAU takes a case in West Virginia, where an UnSub practices his own twisted form of Old Testament vengeance.

With Rossi in Voit’s clutches, he grapples with the limits of his technical know-how and mental strength. As the BAU tightens their grip on Voit, he reveals just how far he’s willing to take his deadly crusade.