Panty & Stocking have to fight against a Ghost in a race of death.

The Ghosts of wasted sperm take over a paper plant, causing a shortage of tissues for men to relieve themselves with.

As a strange pollen causes everyone in town to start picking their noses in ecstasy, Panty and Stocking are invited to a blimp party by Oscar H Genius. However, he turns out to be a Booger Ghost planning to ram into the moon using collective nosebleeds.

When warring robots from outer space land in Daten City, Panty & Stocking eat their cores and become robots themselves to carry out their sibling feud.

Stocking finds herself falling in love with a rude and flatulent Ghost, much to Panty's surprise.

Panty is kicked out by Garterbelt for the loss of her powers, but he secretly helps persuade her, with assistance from her grandmother, to stop Corset from using Brief to unlock Hell's Gate using Hell's Monkey. Panty has sex with Brief, breaking her hymen and restoring her powers. Stocking returns from Heaven and helps Panty take on Corset and the demon sisters.