Kaiji Itou is a bum who's been living in Tokyo for 3 years and gambling his life away, then one day a shady man named Endou Yuuji comes to his home asking for Takeshi Furuhata. It turns out that his friend Furuhata disappeared and left Kaiji with the debt of ¥3,850,000, which will take him 11 years to pay off. But Endou has a proposition for him; he wants Kaiji to participate in the gambling event on the Harumi Wharf.

The event that will decide the fate of Kaiji and the rest of the debtors, onboard the Espoir, is a game called "Restricted Rock Paper Scissors". Following the explanation, Kaiji is then approached by Funai (the other person who borrowed 10 million) and it turns out that he's a repeater. He wants to team up with Kaiji and Kaiji accepts, not knowing what he just gotten himself into.

There are only 5 minutes left and only Funai is left, so Kaiji challenges him to a final match wagering 5 stars. Kaiji has the edge because he knows that either way he will be sent to the "other room" but Funai is reluctant to except this unfair wager. In the other room Kaiji pins all his hopes on being resurrected.

Kaiji is in the other room waiting to be resurrected by his comrades, however Andou is having second thoughts and decides to betray Kaiji by selling his stars. It doesn't take much for his last hope, Furuhata to betray him as well.

Kaiji accepts the invitation to the next party at the Starside Hotel and he recognizes a few familiar faces from the dreadful night on the Espoir. Kaiji is really determined this time not to fall for any tricks however the gambling event this time is "Human Derby" which the spectators are gambling on.

The event is Human Derby, a sick game which plays on ones mind and body and Kaiji must decide to push or be pushed. What will Kaiji choose to do? By the end of the Human Derby, only 21 people out of the total 60 contestants survived. Yet this is not the end of it, as there is a new deadly challenge that waits for them.

10 people including Kaiji have volunteered for the Human Derby on the final bridge, 22 stories high, which spells instant death if they fall. After deciding which order they will go in, the pathway to salvation opens but it may not take much for the monster they've all kept hidden away within themselves to awaken.

At the Starside Hotel 8 people now remain on the 74m bridge-crossing of death. Faced with imminent death, they all want to give up but Yukio Tonegawa ignores their pleas of mercy and in a mere 3 minutes only Kaiji, Sahara and Ishida remain.

With only 2 people remaining, Sahara is the first to survive the bridge-crossing of death however there is something sinister behind the window, before him. With all options out of the question, Kaiji is at a loss of what to do but he eventually finds a loophole that is potentially a path to salvation.

Onto the 9th match, this is the most crucial point for Kaiji who only has 4 more matches and 4mm till destruction. His mind is full of so many conflicting thoughts and even without the confidence in his choice he somehow managed to win to ensure his safety. Yet something feels off about the whole turn of events and through his deductive skills Kaiji realizes that they are cheating.

While Kaiji is on medical duty, he meets the son of Ishida, Hiromitsu, who is also working underground for his debt, but blames his father for not bailing him out. Angrily Kaiji berates him for not accepting his own weaknesses. Later, Kaiji insults Ōtsuki who then makes life a misery for Kaiji and the Forty-fivers, but after three months they all return to full pay. Meanwhile, Kurosaki Yoshihiro, Tonegawa's replacement, observes Kaiji through CCTV. When the gambling night begins, Kaiji proposes no betting limit before he will join in and Ōtsuki accepts.