Tommy starts taking Janet's antidepressants. When Sean meddles in Franco and Laura's troubled relationship he makes things worse. After a gay visitor, the crew wonders about Mike's sexuality.

Tommy copes with a tragedy. Jerry must decide what to do when his wife's condition worsens. Sean has a crisis of faith. Lou learns some shocking facts about Candy. And the crew responds to a multi-level building fire with people trapped inside.

Lou turns to new-age techniques in his efforts to change his life. Sean and Maggie come to a surprising decision. Tommy and Angie continue to see each other, which quickly leads to an embarrassing scene with Janet.

Janet plots revenge when she learns what Tommy did with the baby; Franco questions his marriage proposal to Natalie in light of Alicia and Keela's return; and Tommy faces his ghosts.

A late-night cleanup turns into a nightmare for Tommy when several unexpected visitors stop by the bar. Feinberg allows Damien to ride along with the crew, but may not be prepared for the consequences.