Emily Owens, an awkward first-year intern at Denver Memorial Hospital, tries to balance work with romance. In the opener, Emily begins her internship and discovers her old high-school nemesis working there, as well as a guy she had a crush on in medical school.

Emily learns that the nurses don't like her when she is assigned a difficult case as revenge. Later, Emily reveals her feelings to Will, and considers using a secret she knows about the chief to get a speedy approval on a procedure.

Emily suffers a major embarrassment in front of her colleagues at the hands of a drug-impaired patient. In the aftermath, Emily decides to follow Dr. Bandari's advice and tries to toughen up. Emily and Will find that a teenage patient needs a partial liver transplant, but they uncover some surprising information when neither of the teen's parents is a match. Meanwhile, Cassandra starts treating Emily better in an effort to learn more about Will, and Tyra sets Emily up on a date with her ex, a fact which she doesn't reveal to Emily.

Emily treats an infant and a deeply religious man whose faith is shaken following surgery. Meanwhile, Will breaks protocol with a risky diagnosis; and Tyra considers telling her father that she is a lesbian.

A beloved flower-delivery man collapses, but he is reluctant to get treatment. Meanwhile, Emily and Will are assigned to help a sick prisoner, but they find it difficult to remain professional and not let his crimes cloud their judgment.

When the hospital is inundated with bus crash victims during a winter storm, Emily is assigned to run triage in the E.R. During the chaos, Emily is forced to do an emergency skull procedure on a heroic Marine who suddenly collapses. Tyra bristles at her father’s lack of respect for her as a doctor, but they later experiences a breakthrough when they perform an emergency c-section together. Meanwhile, Will and Emily secretly work to help an unexpected patient leaving Cassandra to question Will’s true feelings for Emily. Micah finally makes a bold decision in his personal life.