Lu fears that a little girl who keeps getting injured might be being physically abused by her dad. Andy suspects her nanny is stealing valuables from the house. Peter gets through to an insensitive husband of a pregnant woman about the pains of carrying a baby.

Dr. Campbell treats a patient for what she believes is alcoholism but she won't admit to her drinking problem. The patient's daughter goes to desperate measure to get her mom to stop drinking. Another of Andy's patients needs to get a kidney transplant but nobody in her family is a match. Tammy's mom then reveals a horrible secret that could save her daughter's life. Meanwhile, Lu, Lana, Peter, and Ben go out on the streets to find out what is threatening the lives of young infants.

Kayla is frustrated when a patient refuses to let her treat her due to her race and her intern status. Andy refuses to treat her and insists that Kayla handles the patient. A complaint is filed against Andy because she refused to treat the patient. A new doctor at Rittenhouse must take over Milo's patients and replace him in the hospital.

Andy treats a beauty pageant finalist and finds that she has a shocking disease caused in part by her breast implants that requires surgery. Also, Andy tries to find time to talk to her friend, a presidential aide who is visiting from Washington D.C. Meanwhile, Lu deals with the pain and struggling of immigrants when a truckload of them show up on her block and is shocked to learn that all twenty of them are pregnant. Jonas invites Lu to dinner with his extended family and Lu gets a toxic surprise. Later, Lu has difficulty finding a fuel-efficient car and a lost box could ruin her relationship with Jonas' family. Finally, Peter and Kayla try to work through the red tape of workplace romance and start a relationship.

After a policewoman uses a stun gun to discipline an 11-year-old boy with behavioral problems, Lu takes a special interest in him and the new technique. Dylan is asked to perform a risky procedure by a multiple sclerosis patient who is willing to risk her life to beat the disease. Kayla finds that a patient has come into contact with the deadly poison ricin and is forced to report it to the U.S. Department of Homeland Security.