An Alzheimer's patient attempts to maintain custody of her 15-year-old son with Down syndrome, and a domestic diva puts the health of her unborn child at risk.

A patient of Dana's gives birth to twins — one baby is black, the other is white. And Lu suspects that a woman with chronic back pain is addicted to prescription drugs.

A pregnant and very ill pro-life politician has her principles put to the ultimate test when the only treatment that will save her life will result in losing her baby. Meanwhile, a patient of Lu's who is trying to pass herself off as a much younger woman is hampered by the inconvenient arrival of menopause.

As Dana's upcoming birthday makes her decide to seek a volunteer sperm donor so that she can have a child, she is confronted with a newborn who is HIV-positive. Lu is accused by an enraged mother of being responsible for her teenage daughter's sexually-transmitted disease because Lu provided the girl with birth control.

Hospital executives approach Dana to perform a risky procedure to save an unborn child's life; Lu treats a prison inmate for cervical cancer and decides to take on the prison system in regard to women's health care.

Also Dana becomes emotionally distraught after her pregnancy ends. Lu tries to stop a patient from utilizing an expensive screening test not covered by the clinic to save the patient's money. And Lu fears an elderly patient may be stashing enough medication for a suicide attempt.

Lu fears that a little girl who keeps getting injured might be being physically abused by her dad. Andy suspects her nanny is stealing valuables from the house. Peter gets through to an insensitive husband of a pregnant woman about the pains of carrying a baby.

Lu deals with the schizophrenic mother who takes her five year old girl who suffers from epilepsy off of her medications in favor of a ""ketogenic diet"" which has stopped all the seizures. Additionally, Andy and Lu have a friendly competition when each one of their patients is studying for a spelling bee. Andy also has to adjust to spending her first Christmas holiday without the kids.

Lu treats a young patient with Bi-Polar disease which causes her to act hazardously violent. Her mother must decide whether to keep her or give her up to a mental institution. Meanwhile, Andy helps a woman have an invitro fertilization. She uses new technology to help the couple have a boy because of a genetic female-only disease in the family but later a web of lies and deceivements is revealed. Peter gets jealous when Kayla dates a man he volunteers for at a zoo.

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