Dr. Campbell files for divorce from her husband while battling a cough. Lu tries to stop a boxer from fighting her next match. Lu tries to get Andy to look at her but she thinks it's just allergies. Andy treats Blain who doesn't feel good.

Lou looks at Lyla who has SIS (Second Impact Syndrome) and wants Lyla to stop boxing because her next match could kill her. Lu heads to the boxing ring to ask Lyla to stop and doesn't listen.

Blain learns she has ATL (Adult T-Cell Leukemia.) Lu tries to track down Andy's chest x-ray thinking she may have Lung Cancer. Dr. Campbell learns she has lung infection.

After Andy saves the life of a gunshot-wound victim, she and Robert must decide whether to accept a donation to the health center from the patient's less-than-reputable father. Meanwhile, Lu helps a breast cancer survivor to overcome her fears about body image and dating after a mastectomy. Also, while planning Jesse's Sweet Sixteen birthday party, Andy must come to grips with the impending financial limitations that her divorce will place on her family. When one of Andy's patients suffers from a heart attack, she and Lu disagree about the cause.

When Andy encounters a young woman with amnesia and her fiance, she must decide which secrets should remain untold. Meanwhile, when a pregnant patient refuses to stop using drugs, Lu faces an ethical dilemma and must decide whether to intervene.

Lu deals with the schizophrenic mother who takes her five year old girl who suffers from epilepsy off of her medications in favor of a ""ketogenic diet"" which has stopped all the seizures. Additionally, Andy and Lu have a friendly competition when each one of their patients is studying for a spelling bee. Andy also has to adjust to spending her first Christmas holiday without the kids.

Ben Sanderson wants to cut screening tests for newborns. A patient of Lu's thinks a patient of Andy's is a fugitive but doesn't believe it. Everyone worries if they will have jobs if Octavian Systems takes over Rittenhouse. Andy is asked to stay on a Rittenhouse, and fights for Dr. Jackson's job.

Lu treats a patient who may SARS the doctors tell patents about SRS as they wait for the lab tests. Ben comforts a patient. Andy worries that she will lose Jesse if she moves to California.