J.D., Turk, Cox, Kelso and intern Denise return to Sacred Heart to teach med school, while new med students Lucy, Drew, Cole and Maya are put through the ringer on their first day of school.

Lucy learns a hard earned lesson about what it takes to be a doctor. Meanwhile J.D. and Turk spot a potential love connection between Denise and the new med student, Drew, as they play matchmakers with a little bit of help from Dr. Kelso.