Ogni giorno al pronto soccorso del County General Hospital di Chicago arrivano persone ferite, doloranti, in fin di vita...

Carter, Pratt, Kovac and Abby are dealing with a woman and her three children who've jumped from a three floor apartment trying to escape from the father. Meanwhile Dr. Lewis becomes Chief of Emergency Medicine, Howard quits his internship and Dr. Corday is facing dismissal.

Neela starts a new job in the emergency room after working at the convenience store near the hospital. On Neela's first day, Pratt expects the interns, Abby, Ray and Neela, to take on a large patient load during their shifts. Pratt turns processing the patients into a competition, in which Ray is clearly going to be the winner.

The last 44 minutes of ex-con & alcoholic Charlie Metcalf's life are in the ER, as he slowly succumbs to end-stage liver failure.

A wounded police officer's teenage son must make a life or death decision. Abby tries to convince a girl needing appendicitis surgery to stay at County, but her fathers wants her transferred to another hospital.

Abby has a dialysis patient in critical condition, but she cannot find his physician, who does not want to be bothered during the holidays.

Two teens enter the ER with gunshot wounds. When one dies, Neela botches telling the next of kin, making the woman hysterical.

When a 16-year-old girl who had received a kidney transplant from her father arrives at the emergency room feeling dizzy, Carter traces the problem to a new drug that the girl was taking to control seizures related to her kidney dysfunction.

While examining a young boy, Pratt finds a suspicious gash across his chest and calls Wendall (recurring guest star MäDCHEN AMICK) for a consult. Kovac and Pratt examine a man who was shot when he confronted his boss with a gun. Jake (recurring guest star EION BAILEY) tries to convince Abby to date him despite his being a student.

Dr. Weaver meets her birth mother, but their relationship changes when Kerrie reveals she is gay. Dr. Carter causes a commotion when he confronts a couple hoping to scam some painkillers.

A soccer mom finds herself completely aware of everything going on around her, but is unable to move or speak after suffering a stroke.

Gallant e Neela, da quando il medico è in Iraq, continuano a scriversi regolarmente. Il medico si scontra ogni giorno con la dura realtà della guerra. Un giorno, Michael chiede aiuto a Neela per il caso di una ragazzina che è stata ustionata e che necessita di cure immediate. Nel frattempo ottiene dal suo superiore una breve licenza di 72 ore per raggiungere gli Stati Uniti insieme con la paziente.

Sam's ex-husband shows up and wants to take Alex on a trip. Gallant is back and Neela hopes to see him before he goes back to Iraq.

Jules 'Ruby' Rubadoux is back in the ER. He's still angry with Carter about the death of his wife.

Morris is named the new chief resident, which makes nobody really happy, except Morris. Meanwhile Luka and Sam are having communication problems, Carter gets a promotion Susan really wanted and Ray finds out a 14-year old who always comes in for free drugs has been raped.

Casualties of a disaster flood the ER, which is short-handed because everyone is at Dr. Carter's going-away party because he's leaving the ER after 11 years. Dr. Pratt looks for the courage to confront his father, Charlie.

Pronto soccorso di Chicago. Un gruppo di medici alle prese con le emergenze più gravi, ma anche con i problemi e le speranze della vita. Kovac decide che è priorità l'intervento su di una donna ferita in un incidente e su di un ragazzino con un trauma cranico, ma ottiene solo il risultato di avere un alterco con Eve e col padre del ragazzino. Abby aiuta una donna a prendere una difficile decisione, mentre fa una scoperta sul dottor Dubenko. Eve modifica il turno di Sam, dal momento che quest'ultima sembra non sentirsi a suo agio a lavorare con Luka.

The rainy night brings in diverse patients including a mother involved in a car accident with her baby, a man with a satisfaction facilitator, and a comatose patient who suddenly wakes up. Also, Sam steps up to Eve and her strict ways and Jerry gets struck by lightening!

A new attending, Dr. Victor Clemente, comes aboard and quickly makes a stir on the ER. Abby's breast cancer patient convinces her to take a long awaited test. Luka befriends a young woman who awakes from a six-year coma. Also, Weaver shows Clemente who runs the ER.

Pratt's half-brother tries to get him to make ends meet with his estranged father. Clemente treats an infant chimpanzee and involves Abby and Neela on the secret case. Eve promotes Sam and her first tasks is to fire a beloved nurse.

A kidnaped girl is the victim of police shooting. Abby is stuck in the middle of a disagreement between Luka and Clemente. Neela receives a phone call from Iraq. Later, Luka and Abby share a kiss.

Gallant impulsively asks Neela to marry her that exact day, she says I do but soon gets cold feet. Morris stands up to Weaver on a patients course of treatment. Luka, Sam and Clemente treat a boy who contracted HIV from his mother. Also, Abby and Luka redefine their relationship and Luka is named the new Chief of Emergency Medicine.

Ray helps an old friend escape from her abusive father. Dubenko volunteers in the ER but can't seem to handle a slow day. Abby and Kovac go baby shopping, while Neela gets unexpected and upsetting news from Gallant.

Dr. Nate Lennox, a former professor with ALS, is brought in as the progression of his disease is chronicled through his own flashbacks as he is treated by each of the doctors at one point. As Lennox wants to give up, Abby fights to convince him to keep on fighting.

An unexpected visitor puts Clemente in the middle of a domestic dispute. Meanwhile, Luka and Abby await test results on their unborn child; Neela struggles with her surgical elective and Pratt ends up with an unexpected suitor when he participates in a charity bachelor auction.