Doc receives a stuffed toy owl named Professor Hootsburgh from her older cousin, but she can't read properly because of her poor eyesight.

Doc rescues Professor Hootsburgh after being accidentally trapped behind Doc's toy box and was accidentally flattened.

Professor Hootsburgh challenges Eggie, an electronic learning device, to a face-off to see who's the smartest toy in the McStuffins Household, but Eggie overheats and starts malfunctioning.

A hurricane hits the neighborhood and Doc helps create an evacuation plan for the toys in the clinic including a "buddy system" but Chilly and Hallie accidentally get left behind when Chilly falls off the wagon during the evacuation and Hallie tries to help keep him calm.

Doc gives her viewmaster toy Viewy Stewie an eye exam and discovers that two of his discs are accidentally jammed together causing him to see images incorrectly.

Itty Bitty Bess and her airplane Queenie (a antique tintype airplane pilot which Doc's mom got from a Flea Market/Swap Meet who was based on "Queen" Bessie Coleman a famous aviator who was the first African American woman to receive an international pilot license) has trouble flying due to rust. So Doc and the crew must help Bess get back into the Wild Blue Yonder.

As Doc's dad reads a bedtime story about Prince Cameron and the giant five-eyed purple monster to her, Doc falls asleep and has a nightmare about the five-eyed purple monster chasing after her, so the toys decide to help Doc overcome her nightmare.

As Doc and the toys are playing School, Chilly decides to pretend to be sick so he can visit the Nurse's Office but discovers that he can't fake a illness just to visit the Nurse's Office.

As Professor Hootsburg plans to paint a portrait of the "plushies", Lambie falls into a mud puddle while doing a pirouette and gets muddy and cannot participate in the portrait. In the meanwhile the Wicked King tries to Photobomb the portrait. As Lambie returns, she discovers that she has lint all over her body and needs surgery to remove the lint from her plush.

Emmie's new toy parrot, Sadie, refuses to talk, so Doc takes Sadie in for a check up and discovers that there's a switch on Sadie's back that causes her beak to glow red and makes her speak.

While playing "Defend the Pillow Fort from the Dragons," a pillow rips, spewing feathers all over the room, but one of the feathers gets imbedded inside Lenny causing him to laugh and squirt water uncontrollably.

Doc's mom gives her a giant named Gillian (from the book), but she doesn’t know how to have a tea party and build a castle. In the meanwhile, Professor Hootsburgh gets stuck in a tree (who rips herself in the process) and Gillian saves her.

Nurse Hattie throws Doc's mom a baby shower.

Doc's mom, gets the call - Baby McStuffins is here! They rush to meet and retrieve the baby and Grandma McStuffins comes to take care of Donny and Doc.

The McStuffins family chooses a name for the new baby: Maya. Also, Lala, the new baby toy ripped her plush and Doc fixes her in the process.

The new baby toy, Lala, has a hard time adjusting to her new home.

Doc enlists Lambie, Stuffy, and Chilly as Toy Med Students to help her take care of all of the patients at McStuffins Toy Hospital.

On their first night shift, Lambie is in charge of the Hospital Nursery but cannot get the babies to sleep.

When baby toy Cece gets dirty, Doc and her toys have to get her clean, and they have to do it fast. Doc's baby sister Maya has just woken up from her nap and wants Cece, but she's too dirty to play with, and that makes Maya cry. Doc tries to give Cece a bath, but every time she tries to get her in the water, Cece cries.

Hallie is so excited after being chosen to sing the opening song for the Foosball Game, she over-practices and loses her voice.

The Toy Med students must learn how to diagnose a patient without Doc's help.

The toys learn about bedside manner as they take care of Karaoke Katie, a doll who is disappointed about having to cancel her show because her batteries won't hold a charge.