When Red provides exclusive intel on an international terrorist, it puts Liz and the Task Force on a collision course with a rival unit from the CIA. Meanwhile, Red and Hawkins lay the groundwork for their new business venture, and Tom goes undercover in search of information.

While Cooper enlists Red on a case of personal importance, Ressler leads the Task Force on a mission to stop the resurgence of once-dormant murder-for-hire ring. Determined to find answers, Tom disregards a warning to halt his investigation into the suitcase.

Red and the Task Force place Dembe undercover to infiltrate an international human smuggling organization, but when communication is lost, they must intervene. Meanwhile, Tom's investigation into the suitcase lands him in grave danger.

Tom goes missing and Liz desperately retraces his steps to find him; Red's hunt for the suitcase of bones leads to lives being changed forever.