After the victims of a car accident are diagnosed with a deadly disease, which caused the accident, a small Maryland town requests the assistance of the NIH team. The only problem is there is only one living victim, as the other nine victims had perished, and in order to save her life, and find the cure, she requires a bone marrow transplant. This little girls runs out of luck as her father has died from the same disease and her mother died from a drug overdose. However, Natalie does some DNA tests to see if the bone marrow can still be used, and discovers the girl was adopted. Eva then then goes and searches for the girl's birth mother, who wants no part in the girl's life. After some tough convincing, Eva gets the mother to donate, and saves the girls life. Now, in order to find the cause for the epidemic, the team must look to some tainted seafood for the answer.

The team figures out that they are dealing with bacterial meningitis, and the only thing that makes their day worse is a corrupt politician who steals the medicine and holds it at ransom. Elsewhere, the people at Mission La Roca (Miles, Connor, Powell, Nestor, Juan, Kris, and Baracas) make it out before the church collapses, and take the sick ones off to the hospital for treatment.