Sadaharu becomes a demon that the Yorozuya tries to rescue with the help of former priestess sisters.

Shinpachi Shimura returns to the Yorozuya and discovers his friends drastically changed during the break. Feeling left behind, he returns home and discovers his sister, Tae Shimura, engaged to Isao Kondo. Tae and Kando enlists Shinpachi into the Shinsengumi and reveals that Tae is pregnant. Shinpachi runs to the ocean and laments the sudden change of those around him. There, he learns about Kyubei Yagyu's sex change to modify her life. They are interrupted by and Kotaro Katsura who also changed his genre due to his Kyubei's characters similarities.

The Madame's arrival is imminent. Kyoshiro, Gintoki, and friends attempt to scout some help, but they end up with a bunch of oddballs. And it turns out that Otae has invited guests from all over town who go wild and leave the bar and Kyoshiro broken! There's no time to worry about taking care of customers.

The complete fallout of the events at Kokujo Island come to light and brings about farewells nobody thought they'd ever see.