Mutsu recalls to Gin how she and Sakamoto first became acquainted.

As Sarutobi attempts to rescue the critically wounded Zenzou, Odd Jobs, Hijikata and Kondou desparately fight back against the ruthless Yato clan, trying to get the Shogun to safety. Meanwhile, Takasugi seeks out Gintoki to end things once and for all.

Tsukuyo and co are caught up in a conspiracy involving an underground drug that causes people to fall in love with the first person they see.

As the Yorozuya struggle with the recent revelations, the Kiheitai find themselves with unexpected allies. Now all will go on a journey to the planet Rakuyou, once the birthplace of two certain redhead Yato.

Umibouzu vs. Utsuro and Kagura vs. Kamui. Though along the way, the father and son reveal the figure who has a connection to all four of them, the deceased wife and mother of three of them, Kouka.

Hasegawa has a life-or-death encounter with assassins, and the Shinsengumi and Mimawarigumi compete over solving a fictional case.

Boogie Diamonds 48 has to deal with the sudden arrival of Galaxy Kingdom Bitches 48, who challenge them for the spot of Edo's top idol!