Kaz and Oliver are trapped in the ER by an evil Skylar and the Annihilator and the two villains plan on taking over the hospital and eventually, the world.

Oliver and Kaz attempt to visit the Annihilator's lair to take his collection of superpowers and restore them to the superheroes.

Kaz and Oliver suspect that there could be a hospital mole that is working with the Annihilator.

Kaz and Oliver know that Skylar is evil, but Skylar doesn't know they suspect anything. They need to keep it that way or she may turn on them as well. They brace themselves until Skylar asks Oliver to the school dance that night.

Oliver and Kaz travel to Skylar's home planet, Caldera, to search for the Annihilator's former mentor, Hapax the Elder.

Kaz and Oliver find themselves ambushed by the Annihilator and Skylar Storm on Caldera. With the help of Hapax the Elder, the boys must find a way to take down the supervillains and save the world.