Masters continues to break new ground by continuing his study as the only white physician in a Negro hospital but at the cost of his gynecology practice. Libby is confronted by Coral's boyfriend, Robert, over her poor treatment of Coral, Betty reunites with her former lover, and Johnson struggles to right her relationship with DePaul - who is newly aware of Johnson's ongoing affair with Masters.

After Hendricks bans Masters from using black participants in his study, Masters contacts a journalist to promote his efforts, using the debunking of sexual stereotypes as the lure. Johnson is forced to accept DePaul's choice to end her chemotherapy treatments. Gene uncovers the truth about Betty and Helen's relationship. Libby fires Coral after discovering she lied about Robert.

Masters and Johnson are interviewed as they take on an exotic new patient.

Johnson jets away with Dan Logan. Masters begins his surrogacy program.

Masters continues his surrogacy program, now under Johnson's critical eye.

Johnson and Masters' troubles come to a head as the trial begins with Keller leading the charge. Virginia does her best to revive their career as Bill faces the reality of what the charges could mean for him, Johnson and the practice.

Johnson looks to get her relationship with Masters back on track while Masters does his best to find satisfaction elsewhere. Betty and Helen ready themselves for a new addition; Art and Nancy discuss the consequences of their party.