Ryuko Matoi is a vagrant school girl traveling from place to place searching for clues to the truth behind her father's death - the "woman with the scissor blade". The journey leads Ryuko to Honnouji Academy.

Having kept her end of the bargain, Ryuko demands answers from her homeroom teacher, Aikuro Mikisugi, and learns the secret behind the power of Senketsu and the Goku Uniforms. Meanwhile, Satsuki Kiryuin returns home to claim a power of her own.

Overwhelmed by recent events, Ryuko demands answers from her homeroom teacher, Aikuro Mikisugi. Meanwhile, Uzu Sanageyama, Honnouji Academy’s Athletic Committee Chair and on the Elite Four, makes a request of his own… to challenge Ryuko to a duel!

Ryuko’s battle against the Elite Four takes to the skies! Meanwhile, more spectators converge on Honnouji Academy. But who is the mysterious girl strolling through town and what secrets does she hold?

Ryuko comes face to face with her father's killer, but can she contain her rage? Mako and the Elite Four look on as sh e rampages on, coming closer and closer to death. Will Satsuki or anyone else be able to stop her?

Satsuki Kiryuin joins the front line of Osaka to battle Kaneo Takarada, the heir to the Takarada Conglomerate. Using the influence of money, Takarada rallies the locals to fight, but Satsuki is suspicious there is another power behind the city's defense.

Preparations are underway for the Honnouji Academy Cultural & Sports Grand Festival! The school is in a fervor as Ragyo Kiryuin will be attending, but what are her and Satsuki's real intentions for the event?

Ryuko's rampage continues, and thanks to Ragyo and Nui she has an unexpected new ally. With Satsuki as the target, will the Elite Four and Nudist Beach be able to withstand the onslaught?

A surprising turn of events catches Nui Harime off guard and gives Nudist Beach a chance to regroup and plan their next step in the fight against Ragyo. But will Ryuko and Satsuki be able to settle their recent conflicts?

The ongoing battle presses towards Honnouji Academy, but Ragyo and the Original Life Fiber stand in the way. Ryuko and Satsuki set off to face them, leaving Nudist Beach's defense to... Mako?! Meanwhile, a crazed Nui continues working feverishly...

The final confrontation is at hand! Will Ragyo and Nui bring on the end of the world, or will Ryuko and the others be able to stop them?

It's graduation at Honnouji Academy, but not everything is as it seems. Ryuko Matoi and the gang must defeat their final enemy.