Deep in the mountains of Western Pennsylvania, John is a small mining community's only defense against an ancient Welsh spirit. In the course of protecting these isolated innocents, John finds a vital new ally in a mysterious young woman named Zed.

John and Zed engage in a dangerous confrontation to save a woman and her family from sinister forces. John's efforts force him to confront the darkness in his own life - while also coming face to face with a new powerful adversary in Papa Midnite.

In New Orleans, Constantine's unusual knowledge of a string of crimes gets him into trouble with Detective Jim Corrigan. He must form an unholy alliance with Papa Midnite when a voodoo ritual to help people communicate with their dead loved ones takes a deadly turn.

John and Zed return to New Orleans when Detective Jim Corrigan asks for their help in the case of a missing girl. Papa Midnite takes steps toward exacting his revenge on John. Meanwhile, the truth behind the Rising Darkness comes to light.