April gets a new assignment at work and reports to a new supervisor, Raquel. Sarah urges Brenna to get an after-school job to learn more about responsibility.

April learns that Dominic has a reputation; Sara introduces her new boyfriend to the family.

April finds the going tough as she attempts to balance everything, including her first bone-marrow biopsy. Leo comes to an assumption about April's motives.

April goes on a joyride with Leo before starting her treatment, and manages to gain insight into his recklessness and the severity of his illness.

April goes to see a fertility doctor before beginning chemotherapy and also seeks advice from her support group about how to reveal her illness to Dominic.

April takes a day off from work to hang out with Beth and people from her support group, and she finds out something surprising about Leo. Brenna goes on a class trip to Miami.

April tries to remain in control of her life, despite having to check herself into chemo. Brenna tries splitting her time between Kieran and Greer.

April's chemo treatments begin to take a toll on her. Dominic realizes how much she has changed when he returns.

An early Christmas celebration happens after April's grandparents pay a visit.

April returns to work and learns there have been major changes at the paper during her absence.

The Carvers are thrilled to learn Natalie is a match for April, until Natalie has second thoughts. April has to re-earn her boss’s trust. Meanwhile, Brenna spends a surprising night out with Natalie, and Beth’s relationship with Graham puts her in an awkward position with Dominic.

April tries to make a new start with Leo; Dominic and April spend an awkward evening together covering the same news event; George and Natalie share unexpected news with the Carvers.

When Beth hosts a house party, April lets loose – a little too loose – which leads to a major blowout with her friend. The new school year finds Brenna feeling alone and bullied. Meanwhile, Leo gets some valuable advice from Sara and ends up getting a job, but he finds the new experience more challenging than he expected.

April gets some welcome news from Dr. Hamburg that bodes well for both her and Leo. At work, she gets wind of a possible story opportunity with baseball player Richie Miranda, but when she gets a bigger scoop than she bargained for, she is faced with a tough moral choice.

April panics about a recent recurrence of her cancer symptoms and her worries increase about the stability of her remission. A desperate search for ways to alleviate her anxiety leads her down unexpected paths. The tension between April and Leo is still palpable, but a twist of fate may encourage them to reconnect. Meanwhile, Sara hosts a college prep meeting for other parents and students from Brenna’s school, and Brenna becomes increasingly annoyed by the pressure of Sara's expectations and worries for her academic future. Beth’s job is taking up all of her time, which has repercussions in her personal life.

April and Beth confide their doubts about each other’s boyfriends and decide to arrange a double date to get to know the guys better. April tries to hide her disappointment when Leo pulls away from the cancer support group while Beth and Graham find themselves at odds over a recent big decision. Dominic gets closer to Natalie after learning they share a sentimental connection, but Natalie worries about what April might think. Meanwhile, Sara wants to keep her latest fling easy and uncomplicated but then learns something shocking about her lover. And, after a fight with her mother, Greer turns to Brenna for support.

The new pick for Editor In Chief at The Post comes as a surprise to everyone, and the pressure is on for April not to let her new boss down. As the competition heats up at work, pitting April and Danny against each other for the next big scoop, April starts to wonder if she is willing to sacrifice everything for success in her career. Meanwhile, Sara is faced with having to sort through Thomas’ belongings from his house in Florida, but she uses it as an opportunity to reach out to Natalie, and to George. Natalie and Dominic feel guilty about their secretive relationship, and they resolve to come clean to April.

April is blindsided by bad news but fights to maintain control over her destiny and to stay strong for her family. She also learns that The Post is cleaning house, but despite her determination to keep her job, extenuating circumstances keep her head on the chopping block. Meanwhile, Brenna learns she is a bone marrow match for an anonymous patient.

Newly engaged and unemployed, April tries to come to terms with her new reality. Always one to think two steps ahead, she decides to no longer plan for her future but just enjoy the moment she is in with a little help from fellow cancer patient Vanessa. First up is to plan and enjoy her engagement party!

April has a weekend getaway with Beth in Bermuda, but it's not the carefree trip they envisioned. Elsewhere, Sara faces some financial troubles; and Brenna finds a sense of belonging at Charton.

Standing in April's shadow, Brenna stifles her true feelings as she leaves Charton and turns to Natalie for support. Dominic attempts to rebuild a relationship with his mom. April goes wedding-dress shopping.

April and Leo are in the throes of wedding planning and coming at crossroads when Sara suggests they take a newlywed quiz to help them learn more about each other. Meanwhile, Sara and Beth try to take a night off from dating drama as Brenna finds herself in a big mess with Margo’s crazy ex.

As the wedding date draws near, April is forced to face a list of “lasts,” such as her last week of living at home and her last time being a single girl. While her natural instincts are to have a classy and low-key bachelorette party, Vanessa helps April realize that this might be her last time to live it up. Another possible “last” opportunity presents itself for April when Dominic sets up a meeting for April with his book agent. With her health still in question, this opportunity may be April’s first (and last) chance to get a book published.

It is the day they have all been waiting for – April and Leo’s wedding day.

April and Leo try their hand at married life, but April worries that Leo has started planning for a future she may not get.

After a shocking traumatic event, April is left reeling and is flung into a world of grief.