When anti-Kappa Dean Cathy Munsch decrees that sorority pledging must be open to all students, and not just the school’s silver-spooned elite, all hell is about to break loose, as a devil-clad killer begins wreaking havoc across the campus.

Chanel finds a new project in Hester, Chanel #3 confesses a secret and Grace and Zayday uncover a surprising connection between two fellow students. Meanwhile, Denise sets her sights on one of the Kappas, and Dean Munsch appoints a new Wallace University mascot as Chad and Earl Grey lead the fraternity on a witch hunt for the Red Devil.

As Halloween approaches, Chanel creates a devious plan after Zayday makes a shocking announcement. Meanwhile Grace and Pete pay a visit to a mysterious woman with ties to Kappa's past. Also, Hester grows closer to Chad, Denise continues her search for the red devil killer and Dean Munsch does everything in her power to keep Wallace University open.

With Halloween just days away, Dean Munsch makes an announcement affecting the campus and, specifically, Chanel's plan to throw a pumpkin patch party in support of her Kappa Kappa Tau presidential campaign. Meanwhile, Grace and Pete lead a search party for a missing friend, which steers them closer to the Red Devil than ever before, and Chanel #3 and #5 learn what life would be like without Chanel.

Dean Munsch is left in a desperate situation when a shocking event leads her to come face-to-face with her ex-husband's mistress. Meanwhile, in an attempt to determine who the Red Devil killer is, the Kappas use a Ouija board to communicate with Chanel #2 from beyond the grave and learn of a wicked plot against one of their own.

Grace enlists Chanel’s help to learn more about KKT’s past, and ends up realizing she might not be so different from her nemesis after all. Dean Munsch goes “psycho” when she becomes the latest target of the Red Devils. Meanwhile, Denise becomes the new house mother of Kappa House and a shocking figure from the past returns.

Denise does little to calm the Kappas' fears when she spins a terrifying ghost story. Meanwhile, Hester's shocking announcement pushes Chanel to the edge, and a familiar face returns to campus as the Red Devil claims another victim.

After the horror-filled events of Thanksgiving, the Chanels decide to celebrate their favorite holiday -- Black Friday, but the Red Devil has plans to stop their shopping spree. When the Kappas conclude that Dean Munsch is the killer, they set a plan in motion to stop her once and for all. Meanwhile, Denise lands yet another job, Chad offers Pete a chance to join the Dickie Dollar Scholars and someone confesses to being the murderer.

Shocking confessions are made as the Red Devil is finally unmasked and the killer revealed.

Years after the murderous events at Kappa House, Dean Munsch purchases an abandoned hospital under the guise of fixing the healthcare system in America. After recruiting surgeons, Dr. Brock Holt and Dr. Cassidy Cascade, as well as medical student Zayday Williams, the Dean shocks everyone when she enlists the services of the disgraced Chanels to join the ranks at the teaching hospital. Meanwhile, secrets from the hospital’s past begin to reveal themselves and a new killer surfaces.

A new patient with a hideous ailment visits the hospital in hope of a cure, but finds a love interest instead. Meanwhile, Chad returns to win Chanel back and, in the process, discovers a dark secret of Brock’s. Then, after another run-in with the killer, Munsch enlists the help of new Quantico special agent Denise Hemphill.

After the latest attack by The Green Meanie leaves everyone shocked and saddened, Dean Munsch and Denise, along with Hester, devise a plan to catch the killer by throwing a Halloween party in the hospital. Meanwhile, Chanel celebrates a different kind of Chanel-O-Ween and attempts to make contact with the killer’s latest victim from beyond the grave. Once the party begins, an outbreak surprises the hospital, leading Brock and Cassidy to jump into action, and another victim falls.

The frightful events of Halloween force Dean Munsch to notify authorities of murders at the Institute, which leads to a surprising influx of new patients. Meanwhile,Chanel is tired of doing dirty work, so she concocts a plan that entails recruiting new patients to join the Chanels. Later, Zayday and Chanel #5 visit a person with ties to the hospital's past; and a new patient's problems have the staff going a bit mad.

In an effort to secure positive press for the hospital, Dean Munsch pitches a risky surgery to Dr. Holt, whose hand begins expressing more of a wild and dangerous personality than ever before. Meanwhile, Chanel #3 forces Cassidy to undergo a psych test to find the root of his condition with surprising results, and Nurse Hoffel sets a devious plan in motion.

The Green Meanie sets its final plan for revenge in motion as Hester makes a bold move to secure her future, and Brock performs a dangerous surgery to save Dean Munsch's life.