Jackson Oz se svým přítelem Abrahamem jsou napadeni skupinou lvů, kteří předtím zmasakrovali autobus plný turistů. Přežít se podařilo jen jedné ženě, Chloe. S tou se teď Jackson pokouší vrátit zpět do tábora, ale cestou se jim porouchá auto a lvi jim jsou na stopě. Mezitím v LA reportérka Jamie Campbell vyšetřuje další útok lvů z místní Zoo. Společně s veterinárním patologem Mitchem Morganem zjišťují, že nejen lvi se začínají chovat podivně, ale i domácí kočky.

Jackson nachází spojení mezi teorií svého zesnulého otce a podivnými útoky zvířat na lidi. Po propuštění z vězení se vydává pátrat po svém nejlepším příteli Abrahamovi a lvi mu připravují další překvapení. Mezitím ve Slovinsku proběhne další zvířecí útok na lidi, tentokrát ho budou mít na svědomí domácí psi.

Jackson s Abrahamem odlétají do Japonska, aby našli zbytek výzkumu Jacksonova otce. Jamie se podaří přesvědčit Mitche, aby ji doprovodil do jejího rodného města v Louisianě a přednesl senátorovi svá zjištění ohledně abnormálního chování lvů v Zoo. Chloe je naverbována do zpravodajské agentury, která vyšetřuje podivné chování zvířat na celém světě. Mezitím v Mississippi zaútočí smečka vlků na věznici.

Jackson, Jamie, and Chloe travel to Mississippi to investigate the prison fire, while Abraham and Mitch go north to trap and study wolves.

Jackson, Jamie and Agent Shaffer search for a chemist in Alabama who has evidence of Reiden Global's role in the growing animal problem. Meanwhile, Chloe, Mitch and Abraham fly to Rio de Janeiro to delay the local government's plan for a massive bat extermination and come up against a ruthless drug lord.

Abraham works to save Chloe and Mitch from a drug lord; Jackson and Jamie continue to work with Agent Shaffer in search of Evan Lee Hartley and the Mother Cell after Leo is killed in the crash.

The team heads to Paris to investigate a group of bears whose trackers have gone offline. Mitch makes a shocking new discovery about the Mother Cell. Chloe runs into her ex-fiancé.

The team discovers a terrifying rat infestation when a cargo ship carrying the bloodthirsty rodents washes up off the coast of Massachusetts. Also, unbeknownst to the rest of the team, Mitch reconnects with his terminally ill daughter in Boston as he prepares to make a trade with Reiden-Global to save her life.

Jamie contacts a fellow journalist in an attempt to expose the truth about Reiden’s involvement in the global animal problem. After realizing Delavenne works for Reiden, Mitch escapes with both the Mother Cell and his daughter’s medication. However, on their way to deliver the medication, Mitch and Abraham come face-to-face with a terrifying army of birds.

On the run as fugitives, the team flies to Zambia to gather leopard DNA in order to manufacture a cure for the abnormal behavior that's affecting animals worldwide. When it’s time to leave, they need to reach out to animal rights activist Ray Endicott to get safe passage out of the country. Also, Chloe makes the ultimate sacrifice to avoid further bloodshed.

Chloe is taken hostage by someone she knows. Jackson and the others are arrive at Zambia to find the leopard to test Mitch's theory of the animal mutation.

Chloe tries to bring light to the rising threat from the animals. Jackson is taken to a hospital and while they are there Mitch works to create a cure. However, there are many obstacles they must overcome.

Jackson and the team make a final attempt to find a cure to the worldwide animal pandemic, but hit an obstacle that may be impenetrable.

Following a shift in violent animal behavior, the team attempt to rescue Jamie and secure the leopard that could hold the key to curing the animal crisis.

The discovery of a shocking mutation comes with potentially dire consequences for a member of the team.

A tragedy strikes the team's only ally within the government, leaving Jackson and the team on their own to stop a surge of animal-related attacks from destroying the city of Geneva, Switzerland. Meanwhile, Dariela discovers something shocking about General Davies; and in the Canadian wilderness, Jamie comes across a troubling detail about Logan.

In an effort to unravel a dark conspiracy within the Noah Objective, the team travels to Vancouver, where it must infiltrate a black-tie event in order to get close to General Davies and stave off an impending animal threat. Also, Jamie and Logan's journey is interrupted when Logan's past comes back to haunt them.

Jaime and Logan arrive at Caraquet, but things are not what they seem. The group tries to save Chloe.

The team travels to Portugal where they square off against a dangerous venom dealer in order to get one step closer to the cure. Also, Jackson's increasingly erratic behavior jeopardizes the entire team.

Mitch digs into Jackson’s past to get the answers they need to make the cure. Also, the rest of the team hunts for evidence related to the triple helix inside a quaint English town.

Jackson learns his mother is missing in Africa, but before he can look for her, he and the team must contend with a hostile force that has overtaken their plane. Also, Jamie learns a shocking secret about Abraham.

Jackson faces the most difficult decision of his life. Also, Mitch reluctantly enlists help from his father, Max Morgan, to investigate the origin of the final set of triple helix animal bones,

With Jackson missing, Mitch and Abraham race to find him before General Davies and the International Animal Defense Group can locate him and prevent the team from making a cure. Also, Jamie, Dariela and Allison make a last-ditch effort to convince the Russian government to drop out of the Noah Objective.

Mitch and Jamie brave an animal attack at the Russian Embassy in Washington, D.C., and Jackson finally gets the answers he’s been looking for from a surprising source.

Mitch and Jamie hatch a daring plan to undermine the Noah Objective once and for all, and the team reunites on the Island of Pangaea where the final pieces of the cure are put in place.

Mitch and Jamie hatch a daring plan to undermine the Noah Objective once and for all, and the team reunites on the Island of Pangaea where the final pieces of the cure are put in place.

Ten years after the animals were cured but at the cost of sterilizing the human population, a new threat rises in the form of “the hybrids,” an army of unstoppable lab-made creatures focused on destroying mankind.

Jackson and Logan discover a link between the hybrid attacks that occur in Portland and New York; Mitch is interrogated by a woman claiming to be his daughter, Clementine; and a new development in Abraham’s research into the sterility crisis endangers his family.

Abraham and Dariela consider making a deal with Reiden Global for personal reasons, and Jamie and Clementine perform a risky surgery on Mitch.

Abraham and Dariela reunite with the team as they try and stop the hybrids from taking over New York City.

While Jamie’s under arrest, she manages to manipulate Mitch and Logan into helping her hunt shepherds, members of a secretive group responsible for sterilizing humans

Mitch seeks to rescue Clementine from her captors, and a glimpse into Jackson’s sister Abigail’s past reveals the origins of the hybrids.

The team sets out on a rescue mission for Abe and Dariela’s son, Isaac. Then, in search of information on a new hybrid, Mitch and Jamie travel to California, where they cross paths with a familiar face from their past.

Abigail holds Jackson prisoner in order to extract information from him that is critical to her secret master plan, and the team faces a mid-air crisis when their plane experiences an electrical malfunction

After Mitch’s alter ego, Mr. Duncan, attacks the team’s plane then flees, Jamie, Abe and Max set out to find him and help.

After Jackson attacks Abigail, the team rushes to save her as her life hangs in the balance.

As the team is trapped inside the plane by toxic spores surrounding them, complications arise during the delivery of Clementine’s baby.

After the team’s plane suffers a catastrophic accident in the hybrid zone, Dariela and Tessa set out on a rescue mission to save them.

The team races to stop the hybrids from breaching the barrier wall by shutting down the last beacon that draws them in.