Dr. Choi treats a teen mother who abandoned her newborn baby in an alley, as the staffers must make difficult decisions about the teen's future. Also, a hypochondriac with chest pains is treated, as is a patient suffering from possible dementia.

Dark family secrets emerge when Dr. Rhodes' father is honored for making a large donation to the hospital. Meanwhile, the Department of Homeland Security arrives when two injured airplane stowaways are brought to the hospital and Dr. Sarah Reese must deliver heartbreaking news to a boy.

Sharon Goodwin puts her job on the line for a patient in need of a lifesaving bone-marrow transplant. Meanwhile, April cares for a homeless man, Dr. Manning's parents arrive, and a couple are injured during their first date by a hit-and-run driver.

A husband makes a request following his wife's death; Dr. Charles tries to reason with a patient who wants to remove his own arm from his body; a child arrives at the hospital after swallowing magnets; Sarah has last-minute thoughts about her residency.

April and Dr. Halstead clash over how to treat an alcoholic homeless man with a broken leg. Also, Dr. Manning continues to grieve over her husband's death; two elderly women with the same symptoms share a surprise link; Halstead mulls over a job offer in California.