三只眼吽迦罗──容貌美，长生不老，拥有三只眼睛的妖怪。

经常迷惑人心，吞噬人的生命。

被吞噬的人成为死人，不会肉体毁灭。

那个死人，额头上出现了“无”字样。

与来自西藏的神奇少女的相遇，彻底改变了身为平凡高中生的藤井八云的日常生活......!

Yakumo and Pai return to Japan from Hong Kong after the Statue of Humanity disappears from the mysterious Mrs. Huang's mansion. Yakumo returns to school and his friends in the hopes of resuming a normal life. But nothing is normal when you're an undead zombie bound to a magical being and demons start attacking your schoolmates on the playground!

Yakumo and Pai return to Hong Kong when the Statue of Humanity turns up in the possession of Steve Long, another Monster Buster, Inc colleague. Before they can reach it, Steve and the statue are kidnapped. Yakumo, Pai, Ling Ling, and Steve's sister Meixing attempt a rescue. But it's all a trap to catch Pai, the statue, and Meixing in a human sacrifice to release the dark spirit of Kaiyan Wang!

Yakumo, Pai, and the crew of Monster Buster, Inc celebrate their recapture of the statue at Madame Huang's estate, but the party is spoiled by a gruesome challenge delivered by a powerful Wu of Kaiyan Wang's. Pai meets the Wu for a showdown at Aberdeen Harbor and half the harbor is destroyed in the aftermath. How will Yakumo continue on without the anchor of his life?