Set against the vibrant backdrop of one of the world's hottest cities - Miami - private pathologist Dr. Beaumont Rosewood, Jr. must crack a case that hits close to home. As he begins his investigation, Detective Annalise Villa gives him a run for his money as they cross paths and are forced to work together to help the Miami PD solve the case.

When an unexpected piece of evidence surfaces in the 305, Rosewood and Villa attempt to solve a serious crime involving a very well-off Miami man. Meanwhile, Rosewood struggles to balance a new romantic interest with the demands of his mother, and Villa runs into trouble on the job.

Rosewood and Villa dive into the hip Miami art scene to catch a serial killer who is on the cusp of creating a "masterpiece." Meanwhile, an impending lawsuit against Rosewood threatens the lifeline of Magic City Lab, and Rosewood tries to protect Villa from his best friend, Mike.

Rosie and Villa find themselves caught in the middle of an explosive investigation that makes them question whether justice really is blind. Meanwhile, as the decks are cleared for Rosie and Villa to finally act on their feelings, Rosie stumbles on some information that forces him to embark on his own private investigation behind Villa’s back. What he finds could change their relationship forever. Also, Pippy and TMI are moving closer to their wedding day, Donna’s behavior leads Rosewood and Pippy to suspect she has a new man in her life and an error from Hornstock’s past comes back to haunt him.

A new captain shakes things up at the East Miami Police Department, and Miami's young, hot-shot mayor gets personally involved when his promising young mentee is mysteriously murdered.

The team is thrown for a loop when the mummified body of a notorious music producer is found on a yacht. Meanwhile, Rosewood is forced to deal with a shocking revelation about Tawnya.

Rosewood, Villa, Slade and Hornstock work to take down a highly skilled group of criminals suspected of a jewelry store heist, and Rosie decides that someone from the inner circle should run a new Magic City Lab on the west coast.