Rosewood and Villa must follow a trail of clues left for Rosie, before another victim falls prey. As things heat up between Villa and Mike, Villa escapes by throwing herself deeper into the case, which inevitably pushes her closer to Rosewood. Meanwhile, Donna intervenes when Pippy decides to give TMI’s absentee mother a piece of her mind. Plus, the Chief position is Hornstock’s, if he is willing to pay a stiff price.

When a patient of Erica Kincaid's dies on the table, Rosewood steps in to help solve what turns out to be the murder of an undercover ATF agent. But when Villa connects with a cold case detective, it turns out this case has more angles than they ever imagined.

The investigation into Gerald's case leads Rosewood and Villa to Cuba, where they confront two new mysteries; TMI brings her former roommate to help decipher evidence.

When a female astronaut is found dead, Rosie and Villa launch into an investigation of America's space program. Rosie navigates new dynamics regarding his latest health issue, and Villa's long-lost brother returns to Miami.