Seven years have passed and Lorenzo hopes to close the accounts with the Pope by obtaining the signing of a peace treaty between the various Italian rulers. Riario hopes to induce Lorenzo to return to open war. While the Magnificent faces this new diplomatic crisis, his mother Lucrezia involves Clarice in the management of the bank. Worn out by the constant clash with Sixtus IV, Lorenzo decides to start his son Giovanni on an ecclesiastical career hoping to increase the influence of the Medici in the Roman Curia. The Treaty of Bagnolo, signed by all the Italian rulers, marks the triumph of the Medici family and Lorenzo, who has become the deciding vote of Italian politics.

Lorenzo begins to show the first symptoms of a serious illness while his political enemies decide to attack him, questioning the solidity and provenance of Medici Bank's capital. Among these, Tommaso Peruzzi, once a supporter of the family, is now eager to bring to light a scandal that would condemn the Medici to exile. To cover up the crime and avoid losses, the Magnificent risks a new war and plans to kill Peruzzi.

Savonarola, who had taken Tommaso's confession, denounces his killing and openly accuses Lorenzo, who however continues to deny. Clarice begins to suspect the truth. To continue his strategy of control over the Holy See, the Magnificent makes a promise that triggers a family crisis.

Lorenzo allows Bernardi to convince him that the only solution not to lose everything is to kill Savonarola, whose following gets bigger and bigger. By now, the friar openly preaches the overthrow of the established order to found a new Jerusalem. Lorenzo's plan is ready and the assassins recruited ...