When Bull and Trial Analysis Corporation (TAC) help a young woman fight a drug patent lawsuit, they’re forced to travel to Callisto, the small Texan town where Bull suffered the only trial loss of his career.

Dr. Bull confronts his past when he returns to his childhood home, assisting in the arson defense of a young man whose contentious ties to the town mirror Bull's own.

Bull comes to the defense of a military intelligence officer who leaked documents, leaving TAC offline and Benny in hot water.

Bull works with top criminal defense attorney J.P. Nunnelly on the first of three cases to repay her for defending Benny at trial. However, they clash over their client, a computer cloud company that is battling the F.B.I. to retain privacy over their customer's flies that could help identify the source of a recent eco-terrorist attack.