While tracking down the dangerous fugitive Aaron Deckard, Mac and Jack face the notorious Colton family of bounty hunters who already kidnapped their mark. Also, Bozer and Riley try to hack into Jack’s CIA file to find out about his history with Matty.

When Matty and the team search for a former government tech who stole classified intel and has been evading capture, they reunite with the Coltons, the family of bounty hunters, who are pursuing the same man for different reasons.

MacGyver gets a shocking surprise when he tries to tell Matty that he’s quitting the Phoenix Foundation.

MacGyver, Riley, Bozer and Leanna go undercover on a college campus to smoke out a deep-cover operative who is recruiting students to carry out deadly attacks around the world. Also, Jack joins bounty hunter Billy Colton in the hunt for a bail jumper but is concerned when he finds out Billy offered Riley a job.

When a vial containing a deadly virus is stolen from the Center for Disease Control in Atlanta, MacGvyer and team race to recover it before the thief unleashes a global pandemic.

Matty’s ex-husband, Ethan, asks her for help when a criminal organization, S-Company, kidnaps his wife and daughter, forcing Matty to decide if she’s willing to commit treason in order to help him save his family. Also, Riley joins Billy Colton and Mama Colton on a mission to Paris and makes a heartbreaking discovery.