In a world where superheroes and villains are very real, unassuming office temp Arthur becomes obsessed with a sinister conspiracy he believes has taken over his City. Everyone thinks he's crazy, except his mysterious new ally, The Tick, a bizarre blue superhero who might just be a figment of Arthur's imagination...

Tick and Arthur have a run-in with local villainess Miss Lint and her gang, who will stop at nothing to get back the mysterious supersuit that Tick took from them and gave to Arthur. Dot, Arthur's paramedic sister, moonlights for an unsavory business.