Penn and Teller roll a lesson about the First Amendment into their entertainment at Zoey's White House birthday party, setting off a media frenzy and public relations nightmare; Baker drops out of the race, leaving the field free for Russell, who asks Josh to run his campaign; Jed takes a hard line on making significant gains on substantive issues in his last China summit; Vinick turns down Jed's offer of the U.N. ambassadorship to run for president; a fully ambulatory Donna has difficulty scheduling a meeting with Josh; Jed has an MS relapse which leaves him partially paralyzed and in a wheelchair.

As acting chief of staff, Josh calls Leo in for backup when the news about Jed's health hits; the staff follows the progress of an asteroid headed for earth; Jed struggles with his relapse as C.J., Kate, and Toby handle the repercussions of his illness on the progress of the China summit; Josh is outraged when Will uses Jed's paralysis as a political opportunity for Russell; Donna resorts to extreme measures when Josh avoids her repeated attempts to sit down for a personal discussion; after receiving some wise advice from Leo about the future, Josh makes a decision about the man he'll support in the upcoming presidential election.

A senator attaches a rider to the federal budget bill that would ban gay marriage, almost daring the President to veto it, as the physical infirmities of Bartlet's MS become more pronounced. The Internet is rampant with a story that questions CJ's sexual orientation, and it is only fueled further when CJ refuses to dignify the allegations by putting out a statement. Donna joins the Vice President's senior staff, and heads for New Hampshire to start up Russell's presidential campaign there. And Santos decides that he will run for president after all, but only if Josh will leave the White House to manage his campaign.

Valentine's Day starts badly when the Iranian air force shoots down a British airliner, killing 100 passengers. The U.K. Prime Minister threatens to retaliate by bombing nuclear reactor sites, which could doom future support for political reformers in Iran. But C.J. has made an agreement with Abbey to allow the President to get more rest, and she is reluctant to awaken him at 5 A.M. to deal with the crisis. Meanwhile, Toby and a visiting law professor answer questions from a foreign delegation that is trying to write a new constitution for the former Soviet Republic of Belarus, and harried staffers pass the buck of Leo's traditional meeting with the new Miss World.