Edie organizes a neighborhood search for the missing Mrs. Huber, just as the absent busybody's sister Felicia Tilman arrives on Wisteria Lane. Meanwhile, Bree resigns herself to her marital state and asks an attractive pharmacist on a date. Susan's ex Karl suddenly reappears in her life, and Lynette fears that Tom is attracted to the new nanny. Lastly, Gabrielle sinks to new depths.. she gets a job.

The residents of Wisteria Lane finally learn Martha Huber's fate. After learning that Mrs. Huber left behind a journal, Susan is forced to confess to Edie about her role in the fire that burned down Edie's house. Meanwhile Bree finds her new beau, George getting a little too close for comfort. Lastly, Carlos returns, but his homecoming isn't quite what Gabrielle had in mind. He is under house arrest, making it difficult for either of them to make money.

When Lynette's father-in-law pays a visit to to the family, she unwittingly learns a family secret. Meanwhile, Susan is disturbed by Julie's growing romance with Zach. Rex attempts to reconcile with Bree as she tries to play hard-to-get. Lastly, Gabrielle is shocked when John's parents ask her for a favor in convincing John to move back home as he officially turned eighteen and no longer wants to live at home and trying to pursue a relationship with Gabrielle.

Gabrielle plans a big party to bid farewell to Carlos, who is about to head off to jail for eight months. Meanwhile George Williams resurfaces in Bree's life, much to Rex's displeasure. Also, Lynette is shocked to learn that Tom's old girlfriend Annabel Foster who he dumped for Lynette has been hired at his firm again. Meanwhile, Zach continues to stalk Julie while Mike tries to separate Susan from Mary Alice's past secrets. Lastly, housewife Gabrielle is suspecting that she's pregnant.

Bree begins to feel guilty about her friendship with George while Rex's health continues to depreciate. Lynette tries to spice things up with Tom who, she fears, is losing interest. Meanwhile, Mr. Shaw consults with Paul, and ends up lying to Susan. After talking with Kendra Susan learns what Mike did. Gabrielle tells John that she is pregnant, and John doesn't take the news well. Lastly, Felicia takes action to help Zach, and to get rid of Paul for good.

Susan and Mike decide to move in together, much to Edie's displeasure. Meanwhile, Lynette takes steps to make sure Annabel doesn't come between her and Tom. Also, Bree comes to a realization about her "buddy" George the pharmacist who continues to interfere in her and Rex's lives. Carlos' legal problems take a turn for the worse, when Gabrielle decides to leave him. Mrs. Huber's journal reveals some secrets. Lastly, two new faces arrive on Wisteria Lane.

Susan is surprised when she finds out who Edie's new boyfriend is. Meanwhile, Lynette has gone back to work, leaving Tom at home in charge of the house. Carlos makes an unusual request to Gabrielle after his life is threatened behind bars. Lastly, pharmacist George reemerges in Bree's life, which sets off an alarm to mother-in-law Phyllis and her suspicions surrounding her son's death.

Susan tries bravely to accept Edie’s new role in Julie’s life, while Lynette’s demanding boss makes her miss Parker’s first day of kindergarten. Bree later on takes a polygraph test to prove her innocence in Rex's death and realizes she has feelings for George.

Gabrielle finally comes to the truth about Carlos and John after seeing John with another woman.

On one of Gabrielle's prison visits to see Carlos she creates a terrible riot, which lands Carlos in hot water. Also, Susan puts her feelings aside and joins Mike in searching for his son Zach. Lynette is surprised to find out that her son Parker has an imaginary friend. Lastly, George and Andrew both vie for Bree's attention as they both compete in making each other look bad in front of her, until one fight goes a little too far.

Susan's longtime book agent and dear friend, Lonny Moon gets into financial trouble. Lynette is forced to go out to bars night after night with her man-hungry boss, Nina. Bree finds out about Rex's feelings about her prior to his death. Lastly, Gabrielle hires hotshot lawyer David Bradley to defend Carlos in court but Carlos rejects him after he witnesses an attraction between David and Gabrielle.

Mike and Susan face a crisis in their relationship when Susan tries to get Paul Young arrested by confessing to a police officer that he killed Mrs. Huber and Mike has her diaries as proof. The officer goes over to Mike to get the story, but Mike denies the whole thing. As Carlos continues serving his jail sentence, Gabrielle valiantly tries to free him. Bree goes to a romantic hotel with George, but requests they sleep in separate rooms.

Gabrielle tries to revisit her past when old friends come to town, but doesn't want anyone to know that she's three months pregnant. With the aftermath of her breakup with Mike, Susan finds temporary solace from her ex-husband Karl as his relationship with Edie hits a bump. Also, the Scavos learn more about the new neighbors, the Harpers when they babysit their children and uncover a sex tape of the couple. Lastly, Caleb gets loose from the basement and roams around Wisteria Lane at night, which leads to major consequences for Gabrielle.

All of Wisteria Lane is panicked by a burglar loose in the neighborhood and thus a neighborhood watch committee is formed. Bree finds out some disturbing information about George. At the wedding of Sophie and Morty, Susan learns who her real father is and is determined to find him.

George stalks Bree, despite her efforts to break up with him. Lynette takes charge of office politics. Carlos is paroled from prison and returns a new man, and Gabrielle is jealous of his new 'holier-than-thou' confidante. Susan meets her birth father and tries to begin a relationship with him.

Flashbacks take us back to to moving-in day on Wisteria Lane for Bree, Lynette, Susan and Gabrielle and how Mary Alice brought them all together. Back in the present, Bree gets some frightening news. Susan moves into a trailer after her house was burnt down. Lynette and the kids are staying at a hotel. After seeing a report on the news, Gabrielle believes Carlos died. Paul begs Zach to get him a good lawyer via Noah.

Everything that begins must eventually end. This episode of beginnings and endings walks us both backwards and forwards as we take our final stroll down Wisteria Lane.