Gaby and Angie challenge each other's parenting skills, Susan befriends a stripper and takes her under her wing, Lynette and Tom argue the merits of their new therapist, and a concerned Bree keeps a watchful eye on Orson for fear he may take his own life.

Gaby risks her safety to help Angie; Lynette's fate and that of her unborn child lie in the hands of Eddie; Susan comes to grips with her financial woes; Bree considers confessing a secret she's harbored for years; and Angie must submit to Patrick's demands in order to protect her son.

Gabrielle desperately tries to figure out a way to keep Grace in her life; Keith plans a very special dinner with Bree; Tom is angry at Lynette for not disclosing his special attributes to the other ladies; Renee tells Susan a deep, dark secret; and Paul's plan for Wisteria Lane is revealed

Paul's nefarious plan for Wisteria Lane is put into full effect. Juanita discovers that she isn't Gabrielle's biological daughter, and Bree invites Keith (guest star Brian Austin Green) to move in with her, whilst Tom is confronted about his past indiscretion with Renee.

Susan vows to get the most out of life when she learns that her dialysis isn't working and that, unless she receives a kidney transplant soon, she will die. Meanwhile, jealous of Lee and Bob's adopted daughter's routine for an upcoming school talent show, Gaby pressures Juanita to come up with a number that will outshine everyone; Bree makes it her mission to find a kidney donor for Susan; Lynette puts a plan into action to discourage a clearly non-maternal Renee from adopting a baby; and Beth Young struggles to figure out what to do with her life after Paul kicks her out of the house.

Paul tries to stand between Susan and her kidney transplant; Felicia is released from prison and swears revenge against Paul; Gabrielle is furious about a neighborhood party planned by Renee; Tom is caught between working with Carlos and a job opportunity; Andrew's drinking concerns Bree.