Germ warfare becomes personal when Kilmer risks exposure to an extremely deadly gas in order to stop a widespread catastrophe.

The Team must work together in Africa and stateside in order to prevent an airliner filled with deadly nuclear waste from crashing into the East Coast of the United States.

In an effort to stop an assassination attempt on a major political figure, Frankie interrogates the one man who knows the potential suspect's identity. When her detainee dies in custody, it's up to Kilmer to find the would-be murderer in order to clear Frankie's name.

Atkins is reunited with a Russian agent and an American double agent from his past when the team attempts to prevent poisoned money from reaching wide circulation.

One of the Threat Matrix team is killed in an attempt to prevent the North Korean Prime Minister's daughter from being kidnapped.