Dr. Murphy treats a patient who has an illness that is not only unpredictable in nature, but also unlike anything he or the team has seen before. Dr. Claire Brown continues to work through her grief, still reeling from Dr. Neil Melendez's death.

Shaun has a hard time balancing his fears and concerns about potentially jeopardizing Lea's health and wanting to be with the woman he loves. Claire looks for a way to grieve Melendez's death. Park and Mia discuss their future together.

With several candidates vying for residency at St. Bonaventure, Chief of Surgery Dr. Audrey Lim tasks Dr. Shaun Murphy, Dr. Claire Browne and Dr. Alex Park with mentoring the top first-year resident contenders. As their mentees shadow them for the day, Shaun and Park meet with Andrews to discuss a difficult surgery scheduled for a minor. Later, Shaun inadvertently insults Lea while discussing the pros and cons of the controversial surgery. And elsewhere, Dr. Morgan Reznick seeks out Claire and Lim’s help on a consult.

Dr. Morgan Reznik and Dr. Shaun Murphy's pregnant patient with twins is having pain and they are forced to grapple with a decision no one wants to make. Meanwhile, Shaun asks Lea to move back in despite her reservations

Dr. Shaun Murphy questions his decision to give the new residents autonomy when one of his intern's misdiagnosis of a patient has dire consequences. Meanwhile, Dr. Claire Browne, Dr. Alex Park and Dr. Jordan Allen treat a patient with a ruptured cyst affecting key functions of her brain. And elsewhere, Dr. Morgan Reznick and Park bond over failed relationships.

As Chief of Surgery Dr. Audrey Lim struggles to cope with the residual emotional trauma of COVID-19, she encounters a young war veteran fighting debilitating PTSD. After discussing his case with the team, Dr. Claire Browne suggests a radical treatment to help him. Meanwhile, still reeling from the recent loss of his mentee’s patient, Dr. Shaun Murphy declares he doesn’t want to teach the new residents anymore. And elsewhere, an eccentric patient keeps the team entertained.

Dr. Morgan Reznick discovers her patient’s wealth and obsession with extending his life is a dangerous mix that could end up costing more than he can afford.

The team treats a teenage gymnast who experiences complications from her intensive training. Meanwhile, Shaun meets Lea's parents for the first time.

Lim is challenged by the unique circumstances surrounding a pregnant patient with an aggressive tumor. Elsewhere, after misdiagnosing a patient, Claire makes a disconcerting discovery about certain practices at the hospital.

When the hospital is hit with a cyberattack threatening to shut down life-saving machines, Lea rises to the challenge and looks to outsmart the hackers to prove herself. Meanwhile, the team treats an inspirational cancer survivor-turned-successful-philanthropist who harbors a dark secret.

After bringing in an incredibly unique and complicated spinal surgery, Dr. Aaron Glassman challenges the residents for an opportunity to join him in the operating room. Meanwhile, Shaun and Morgan disagree on how to treat a comatose patient with a cancerous tumor.

When a renowned surgeon comes to St. Bonaventure for treatment, the team’s enthusiasm is quickly overshadowed by the doctor’s behavior. After studying his case, Dr. Shaun Murphy sees a pattern he recognizes. Meanwhile, Shaun and Lea are forced to make a life-changing decision that will alter the course of their relationship.

Claire is blindsided when her absentee father shows up at her door. Meanwhile, Shaun feels disconnected from Lea, causing tension in their relationship.

After finding out the gender of their unborn child, Lea's enthusiasm prompts Shaun to make an effort to be a more supportive partner. Meanwhile, the team treats a navy pilot whose previous doctor's misdiagnosis compromises her chances at a full recovery.

After a political protest turns violent, the team races to save two young gunshot victims.

Shaun struggles with his role as Lea's partner after complications arise with the pregnancy and his instincts as a medical professional kick in. Meanwhile, Dr. Park, Dr. Andrews and Asher disagree on how to address an elderly patient's wishes.

Dr. Claire Brown and the team must face hard truths about what lines they are willing to cross when one of Claire's idols becomes her patient.

Shaun and Lea go on a camping trip to distract themselves from their grief over their miscarriage. Meanwhile, Morgan and Park argue about the best course of treatment for their patient.

The St. Bonaventure team travels to Guatemala on a surgical mission to help patients at a rural hospital. Once there, the team faces a small community that is in desperate need of their help but are assigned the daunting task of identifying who they can help most. And while Shaun seems to be thriving in Guatemala, Lea is still struggling with the loss of her baby.

Dr. Shaun Murphy must perform a risky surgery on a patient without electricity when the power suddenly goes out. Meanwhile Lim and Dr. Mateo Rendón Osma’s relationship deepens as they overcome difficulties during the surgery.

Shaun and Lea's upcoming engagement party has everyone in a festive mood; a young single mother learns her son may have contracted his cancer from a surprising source; Mateo finds out if his previous issues in America will be resolved.

Dr. Shaun Murphy and the team race to save a pregnant woman's baby and find her current situation as a convicted felon complicates it even more than they realize. Meanwhile, the hospital takes on some unexpected changes that the staff are not prepared for.

Shaun confronts Salen about the many changes she has implemented since coming on at St. Bonaventure. Glassman is forced to accept his new role at the hospital.

Dr. Shaun Murphy and the team treat a young girl whose father’s personal research complicates their treatment plans. Meanwhile, Dr. Park, Dr. Reznick and Dr. Lim’s patient refuses a life-saving lung transplant despite having a family donor.

Dr. Park and Dr. Murphy treat an elderly Asian man brought to St. Bonaventure by his daughter after being the victim of a hate crime. In addition, Lea goes behind Shaun’s back to help raise his negative patient satisfaction scores.

Dr. Shaun Murphy and Dr. Alex Park must grapple with a life-and-death decision and decide between saving one patient over another. Meanwhile, Dr. Morgan Reznick goes a little too far in her attempt to win Salen’s favor.

Shaun and Lea happen upon a terrible car accident and discover a young pregnant mother who has been badly injured and needs immediate medical attention. Dr. Glassman is apprehensive when a figure from his past reaches out for help.

Now that Shaun has called off the wedding, he is forced to confront Lea about their relationship and determine what he really means to her. Meanwhile, the team debate their opinions on plastic surgery and Dr. Audrey Lim hopes to expose Salen’s cover-up over an infant’s death to take her down before it is too late.

In an effort to please Salen, Andrews takes on a high-profile case and assigns Shaun and Allen to help perform a risky surgery to restore the voice of a famous pop star.

Salen takes extreme measures when she learns that the surgical staff have joined Lim's efforts against her. The team treats a liver transplant patient whose organ donor unwittingly gave him cancer.

Dr. Shaun Murphy makes a personal connection with a precoious young patient which threatens his objectivity. Meanwhile, while volunteering at a long-term care facility, Dr. Morgan Reznick realizes she could help Dr. Aaron Glassman’s clinic by offering telemedicine services for nursing homes and care facilities.

Drs. Lim, Park and Wolke treat a woman with Valley fever and discover a secret she has been hiding from her fiancé. Meanwhile, Drs. Murphy, Allen and Andrews treat a 45-year-old virgin and help her make a big decision about her life.

While Drs. Lim, Murphy and Wolke help a teenage “biohacker” whose self- experiments begin to compromise his health, Drs. Morgan, Park, Jordan and Glassman treat a young woman who wants a controversial surgery to treat her depression and chronic pain. Additionally, Dr. Reznick looks to take the next step in her relationship with Dr. Park.

When someone mistakenly brings a hallucinogen-laced dish to the hospital's company potluck, much of the hospital staff and doctors are incapacitated -- leaving doctors Murphy, Glassman and Allen forced to take on all the hospital's cases, further exacerbating Dr. Murphy and Dr. Glassman's conflicting work styles.

While Doctor Andrews treats a foster kid for injuries sustained at his group home, Shaun and team look to Lea's expertise with cars and auto repair to help a patient whose iron lung has broken. Meanwhile, the patient's niece, a documentarian, takes an interest in Shaun.

As Shaun and Lea head toward their wedding day, a documentary film maker has chosen to follow their lives to showcase relationships and weddings of atypical couples.

Sophie takes Lea out for a day full of luxurious wedding planning. And after a near fatal oversight, Dr. Lim senses an underlying issue is behind nurse Villanueva's unprofessional behavior.

Shaun and Lea make a big life decision and are pleasantly surprised by the support they receive from their friends at the hospital. Meanwhile, when Dr. Wolke's parents show up with a revelation, Asher struggles to accept that he and his father may never truly understand one another.

Shaun and Lea’s long-awaited wedding reception is interrupted by a violent attack at the hospital and the entire team must mobilize to save the victims. Meanwhile, the trauma of seeing people he cares for in life-threatening situations is affecting Shaun in more ways than one.

On their first day as surgical attendings, Dr. Shaun Murphy and Dr. Alex Park are introduced to the first year residents they will be overseeing, Dr. Danica Powell and Dr. Daniel Perez,who make quite the first impression. Meanwhile, Lim returns to work while facing her new reality and the emotions surrounding the changes.

The team treats a famous marriage counselor after she injures her ankle from falling, but when she offers relationship advice to them, Dr. Morgan Reznick quickly spots that their patient might be experiencing something far more serious. Meanwhile, Dr. Audrey Lim is determined to get to the bottom of what really happened in the OR during her surgery and sets off on her own internal investigation.

The team operates on a military reenactor whose attempt at authenticity has created an explosive predicament that even Dr. Shaun Murphy couldn’t predict. Meanwhile, Dr. Jordan Allen and Dr. Daniel Perez are on a race against time as they search for a severed foot.

Shaun, Asher and Powell treat a young patient on Halloween with a rare hereditary disease, sending them down an uncharted path. Meanwhile, Glassman and Shaun must overcome their differences to work together to try and find a solution for Lim’s paralysis.

In the midst of a heatwave, Dr. Shaun Murphy and Dr. Danica Powell are at odds when it comes to their patient’s surgery. Their heated stalemate tests Shaun’s patience and his willingness to compromise. Meanwhile, when the hospital loses power, Lea and Dr. Aaron Glassman are forced to come up with a quick solution or risk a total shutdown that could risk patients’ lives on the 100th episode.

When a woman pregnant with sextuplets arrives at the hospital, Dr. Marcus Andrews must split the doctors into teams to ensure their health and safety following their high-risk delivery. Meanwhile, Shaun and Lea must face their own hurdles as they discuss starting a family.

Drs. Shaun Murphy, Asher Wolke and Aaron Glassman meet a patient with an infected surgical sponge that was left in their abdomen. Meanwhile, Dr. Morgan Park must face her own past when she treats the victim of a sexual assault.

Dr. Shaun Murphy unknowingly creates a competition between Drs. Danica Powell and Daniel Perez when he introduces a new performance rating system; Dr. Morgan Reznick may have crossed a line with Dr. Alex Park.

Shaun and Lea soon learn that their surprise pregnancy may also come with additional complications. Meanwhile, Doctors Park, Reznick and Allen treat a teen with Gardner’s syndrome whose past surgical history jeopardizes the outcome of his current one.

On the way to their babymoon, Lea and Shaun get a quick lesson in parenting when they rush to aid an injured dog. Meanwhile, Dr. Danica Powell secretly performs an operation on a friend that could jeopardize her career.

Shaun invites Aaron to stay with him while he has exterminators at his house and Lea realizes both men have a lot more in common than she realized. Meanwhile, Dr. Morgan Reznick wrestles with a big decision about her career and her personal life.

Shaun and Lea clash over their parenting styles and worry about what will happen to their relationship when their child is born. Meanwhile, Dr. Lim must find a way to save the damaged lungs that one of her long-time patients has been waiting for.

When a 3-year-old arrives at the ER, the team immediately recognizes he is having a stroke. However, Dr. Shaun Murphy’s diagnosis of the underlying cause doesn’t solve the problem which has Dr. Park search deeper.

Dr. Jared Kalu makes a surprise return to San Jose’s St. Bonaventure Hospital with his billionaire patient. Meanwhile, Park must treat the man his wife had an affair with and try to find a way to forgive him.

Dr. Shaun Murphy seeks legal representation to help him win a case and puts his faith in a promising, young lawyer who has obsessive compulsive disorder.

Dr. Shaun Murphy must learn how to work with Dr. Jared Kalu again and remind him that he must start all over at St. Bonaventure. Meanwhile, Dr. Murphy treats a teenager suffering from neurological problems with a very high-risk procedure.

When a patient comes in with persistent and lingering COVID symptoms, the team discovers she may be dealing with something harder to treat. Andrews and Villanueva must contend with their hierarchy at the hospital and its effect on their relationship.

Drs. Andrews and Lim clash over a patient split nearly in half, which also reveals her issues with Dr. Kalu’s return. Meanwhile, Dr. Glassman gives Dr. Murphy some fatherly advice as they await news about Glassman’s recent tests.

Dr. Marcus Andrews introduces some of the team to a patient whose optimism and faith seems to cause Dr. Asher Wolke the most skepticism in light of his own relationship with religion.

Dr. Glassman and Dr. Murphy's relationship may be irreparably damaged following a tense moment during surgery. While Dr. Reznick struggles during her parental leave, Dr. Park may just be the one she needs the most.

Shaun and Lea are heading to the delivery room and everyone from the hospital is also there, except for one very important person. Meanwhile, a tragic accident involving Drs. Perez and Kalu pulls everyone away, including Dr. Murphy.

Shaun and Lea adjust to parenthood as they debate the importance of schedule and routine for Steve. Meanwhile, Shaun takes on his first case back at the hospital with two baby patients in need of the same heart.

Shaun struggles to accommodate the newest member of his surgical team, Charlie, who interferes in a patient’s relationship with his daughter. Elsewhere, Park tackles a tricky brain tumor, and Lea and Morgan adjust to motherhood.

Shaun continues to be tested by Charlie when their newest case prompts her incessant stream of questions – all in pursuit of an answer. Meanwhile, Morgan struggles on who to name as guardian for Baby Eden should anything happen to her.

Shaun and Lea struggle to balance their parental duties with their personal lives. Meanwhile, Park and Morgan try to find the time and space to reignite their romance amidst the demands of parenthood and work, and Lim's mother makes a surprise visit.

Asher's views on the construct of marriage complicate his future with Jerome. Meanwhile, Asher also briefly revisits his religious past to aid a patient's conversion to Judaism for his fiancée.

The team must deal with a mass casualty event that forces them to put aside their emotions following a recent tragedy.

Shaun and Jordan's patient is in dire need of a kidney transplant. When they find the perfect donor, they also discover that he believes he is Jesus which could compromise his ability to give consent to the surgery.

Shaun, Jared and Charlie's young patient need his parents to agree on an important medical decision that could greatly improve his health; however, his parents are unable to agree on the correct path which spurs the team to try and intervene on behalf of their patient.

Dr. Claire Browne returns from her work in Guatemala for a personal medical examination. Elsewhere, Dr. Glassman struggles to manage Hannah, who remains unresponsive to his attempts to help. Park seeks out the perfect last-minute wedding location.

As the doctors consider their futures, they work together to solve one of the most important cases of their careers.