9-year-old Sheldon Cooper is a once-in-a-generation mind capable of advanced mathematics and science but learns that isn’t always helpful growing up in East Texas, a land where church and football are king.

When Sheldon moves to Dallas to attend a school for gifted children, the family struggles to cope with his absence.

When flu season hits Medford, Sheldon takes extreme measures to remain healthy.

A disappointing loss at the science fair sends Sheldon’s life in a new direction.

Things spiral out of control when Sheldon boycotts his favorite bread company. Also, Georgie offers Veronica a shoulder to cry on when she's dumped by her boyfriend.

Inspired by his hero, Albert Einstein, Sheldon tries his hand at the violin. Also, Mary and Connie secretly buy a pregnancy test when Mary thinks she's pregnant

Sheldon moves in with Dr. Sturgis for the weekend to see what his life will be like in college. Also, a lonely Mary tries to bond with the other Coopers during Sheldon's absence.

Unhappy that school funds are going towards football rather than academics, Sheldon decides to run for class president.

The University makes George Sr. a lucrative job offer in the hopes of recruiting Sheldon. Also, Georgie gets a job working for Connie's new boyfriend, and Mary is determined to rid her home of greed.

Sheldon fakes being sick to avoid a swim test at school. Also, Dr. Sturgis spies on Connie's new boyfriend.

When Sheldon learns the house next door is for sale, he takes it upon himself to find the perfect neighbors. Missy is torn when she’s forced to pitch against her boyfriend at the baseball game.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Connie is furious when she learns Dale fired Georgie.

After graduating high school, Sheldon has a breakdown when he realizes he may not be ready for college. Dale tries to make amends with Connie.

Connie takes matters into her own hands when Sheldon's philosophy teacher, Professor Ericson, sends him into a tailspin. Also, George Sr. learns Georgie has been cutting class.

Sheldon is caught in a moral dilemma when offered a bootleg copy of a computer game he can't afford. Also, Mary and Connie take Brenda out for girls' night while George Sr. and the guys watch Billy, and Missy asks Georgie to take her and Marcus on a secret date.

Sheldon tries to convince Dr. Sturgis to return to the university. Also, Georgie upsets the family when he makes a life-changing decision.

Sheldon gets the science yips and has to learn how to not think. Also, George Sr. plays handyman at Brenda Sparks' house.

Sheldon acts as Mary's spy during a youth lock-in at church. Also, Georgie is attracted to an older woman, Mandy.

Sheldon makes friends with his dorm neighbors; George Sr. learns his job is in jeopardy.

Sheldon butts heads with Dr. Lee, a new scientist in the lab. Also, Mary is given a lotto ticket.

As the church congregation gossips about Georgie, Missy stands up for her brother, and Sheldon is distracted by the family drama.

Sheldon struggles to cope with the first signs of puberty. Also, Mary and George Sr. hunt for new jobs, and Georgie and Meemaw take a business trip across the border.

George Sr. is asked to help with the football team. Also, Mandy discovers Georgie and Connie's secret business.

Sheldon considers dropping out of college to focus on building his database. Also, George Sr. is frustrated when someone else gets credit for his football wins.

George Sr. is worried that Mary wants another baby and gets a vasectomy behind her back. Meanwhile, Drs. Linkletter and Sturgis go to Sheldon for science tutoring.

George Sr. gets an exciting job offer, and Sheldon prepares for his move to California.

The Cooper family grapples with the death of George Cooper Sr.