Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. The doctors perform a risky brain surgery. Mina discovers that Adaku has a dangerous heart condition.

Nic and Mina treat a patient battling a failing heart VAD, forcing them to find a new battery to save her life. Conrad gets a call from a patient who is in crisis. Cain tries to get close to Bell's business partner from the supplement company.

When Nadine's father comes to town for her birthday, Devon enlists help to ensure that he makes the best first impression. Red Rock decides to cut the entire OBGYN department. Nic cares for a teenage patient whose condition is deteriorating.

A renowned pediatric cardiac surgeon proves unfit for surgery. A Dolly Parton drag queen collapses on stage. Nic and Conrad suspect a patient may be the victim of sex trafficking. Nadine delivers some surprising news to Devon.

On Nic's first day back at Chastain, the man who attacked her is admitted to the ER, causing her to confront her trauma head-on. Cain, now in recovery, is self-conscious of his physical state and sets his eye on taking down Mina. The new intern both struggles and shines throughout her first day, causing Devon and Conrad to wonder if something bigger is going on.

A case becomes personal for the staff when Conrad and Bell treat a pregnant woman who is carrying Jake's future adopted child. Upon hearing surprising news from Princess Nadine, Devon contemplates the future of his love life. On the heels of meeting The Raptor's parents, Mina gets a call that causes her to make a bold decision about her future. Meanwhile, Cain grows closer to Rose and Irving and Jessica tie the knot.