In the run-down slums of a futuristic city, the boxer only known as Junk Dog is making a living throwing fights for the mob in underground arenas. That all changes when he has a chance encounter with the champion, Yuri.

Yuri has sought Junk Dog out to test his mettle in the ring, and their encounter will leave the underground fighter a changed man.

Aragaki is a formidable fighter who aims to destroy Joe at the watchful eye of Nanbu, but Joe will not give up and will follow the teachings of his coach until the end

It's man vs machine, as "Gearless" Joe squares off against Shirato Mikio, who is guided by Ace, an artificial intelligence of his own design.

Joe faces off against the bloody lion, Glen Burroughs. If he wants his friends to live, he'll have to throw the match. After coming this far... is there nothing else Team Nowhere can do?

Joe has risen to the top and finally gets his chance of a rematch with Yuri. Yuri himself also feels joy in his chance to fight with Joe. The final battle begins!