After returning from Alcatraz, Bumpy Johnson seeks to regain control of Harlem. With the streets controlled by the Italian mob, Bumpy must take on the Genovese crime family, led by Vincent “Chin” Gigante.

Cassius Clay battles local boxing hero Doug Jones in the ring. Mayme insists Bumpy back Jones, an advocate for her Harlem Youth organization, but Malcolm urges Bumpy to back Clay. Meanwhile, Chin engages in a turf war for Harlem with Bonnano.

Due to slum conditions in Harlem, Adam Clayton Powell Jr. leads a rent strike and investigates the owners of the buildings. Ernie Nunzi searches for the hooker who helped set up Zambrano. Bumpy and Mayme experience tension in their marriage.