Following Mr. Nobody’s capture of The Chief, the Doom Patrol investigate the mysterious albino donkey and discover it’s a door to another universe, where Mr. Nobody is in control.

The Doom Patrol set out for Paraguay where they discover the Nazi doctor who created Mr. Nobody and the connection between The Chief and the two villains.

Jane, Larry and Rita visit a school where the original Doom Patrol has retired. Meanwhile, Cliff & Vic bond over their mutual “father issues.”

After a violent outburst from Cliff, the team engages in some self-led group therapy – leading to some growth within the group as they are knit closer together.

With Vic captured and held at the Ant Farm, his father hatches a plan with the rest of the Doom Patrol to break him out. Naturally, things go awry.

The Doom Patrol tries to restore the memories and abilities of Flex Mentallo, while Rita confronts her self-doubt and Larry realizes how tied he is to the Negative Spirit.

The Doom Patrol enter the Nobodyverse to save the Chief.

The Doom Patrol go their separate ways in the season finale.

Dorothy finalmente consigue una amiga en Baby Doll, hasta que la hora de juegos se sale de control. Cliff descubre los planes de Niles de hacerle algunas actualizaciones más “humanas”. Vic elabora un plan para recuperar a Roni. Luego de una terrible audición, Rita acompaña a Larry a romper el hielo con su familia y aprender más de la vida que dejó atrás.

Mientras Niles y Cliff buscan a Dorothy, Larry debe atender al “viejo” equipo de investigación de Niles. Entretanto, un funeral en el Inframundo ocupa la mente de Jane y Vic nota una extraña conexión entre Roni y S.T.A.R.S. Labs. Rita descubre que su rol en una obra de teatro comunitaria es más cercano a ella de lo que esperaba.

Dorothy and the Candlemaker finally face-off, while the Doom Patrol – now freed from their wax encasings – face troubling side effects. Rita holds the key, but is she ready to answer the call?

A relaxing vacation to escape the Doom Patrol’s recent loss proves anything but – especially when an unexpected evil lurks nearby.

The newly “undead” members of the Doom Patrol are inspired to work on themselves. Later, the team is rocked by the arrival of a mysterious woman on a time machine – and a former foe.

Madame Rouge enlists the Doom Patrol’s help after learning about her unsettling past. While the rest of the team works to infiltrate the target, Rita stays behind and finds a surprising connection with their mysterious friend.

While the fog obscures more than just the air, Vic, Cliff, Jane, and Larry must relive their most shameful moments until a breakthrough occurs, and Rita begins to better understand Madame Rouge.

With Madame Rouge vying for her old spot in the Brotherhood of Evil, the Doom Patrol brace themselves for their impending visit.

As they struggle to function as a cohesive group, the Doom Patrol are confronted by a horrifying realization in the future.

After believing she's uncovered the source of Immortus' power, Rouge tries to convince the Doom Patrol to help excise it.